Background: Human genetic resources are an important material component for life science research and have strategic significance for medical science and technological innovation. In this study, we employ frameworks from social psychology and the science of human behavior to study human genetic resource providers. Aims: We used structural equation techniques to explain factors affecting the intention to provide human genetic resources and the mechanisms for providing such resources. Methods: We conducted an online survey with respondents from ethnic minorities (n = 912). Our model integrates key variables informed by the theory of planned behavior (TPB), the theory of benefit and risk assessment (BRA), as well as variables that represent the policy and political system. Results: Our results show that the factors affecting the intention to provide human genetic resources, ranked from highly influential to less influential, are perceived benefits, privacy risk, attitudes toward providing human genetic resources, perceived behavioral efficacy, psychological risk, subjective norms, and physical risk. The variables informed by the TPB all have a significant positive effect on the intention to provide human genetic resources. With the exception of physical risk, the variables informed by the theory of BRA have a significant effect on the intention to provide human genetic resources. Respondents with different health conditions have significantly different levels of physical risk. Conclusions: The results of our study provide insights into how to improve people’s intention to provide human genetic resources. We also proposed ways to protect such resources globally.

中文翻译：

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评估提供人类遗传资源的意图：一个解释性模型

背景：人类遗传资源是生命科学研究的重要物质组成部分，对医学科技创新具有战略意义。在这项研究中，我们采用社会心理学和人类行为科学的框架来研究人类遗传资源提供者。目的：我们使用结构方程技术来解释影响提供人类遗传资源的意图的因素以及提供此类资源的机制。方法：我们对少数民族受访者（n = 912）进行了在线调查。我们的模型整合了由计划行为理论 (TPB)、利益和风险评估理论 (BRA) 以及代表政策和政治制度的变量提供的关键变量。结果：我们的研究结果表明，影响人类遗传资源提供意愿的因素从影响力从高到低依次为：感知利益、隐私风险、对提供人类遗传资源的态度、感知行为效能、心理风险、主观规范和身体风险。 . TPB 告知的变量都对提供人类遗传资源的意向有显着的积极影响。除物理风险外，BRA 理论所告知的变量对提供人类遗传资源的意图有显着影响。具有不同健康状况的受访者具有显着不同的身体风险水平。结论：我们的研究结果为如何提高人们提供人类遗传资源的意愿提供了见解。