Encephalopathy related to Status Epilepticus during slow Sleep (ESES) is an age-dependent syndrome characterized by the appearance of neuropsychological and behavioral disorders associated with extreme activation of epileptic activity during sleep. The major goal of therapy in ESES is to prevent neuropsychological deficits. Effective therapy to reduce seizures and resolve the EEG pattern of status epilepticus during sleep (SES) may be crucial to improve long-term prognosis. However, whether to improve neurodevelopmental deficits by suppressing or eliminating SES remains unknown. The purpose of this article is to review current therapeutic options in ESES, in order to provide better alternatives. Treatment options consist of antiepileptic drugs, steroids, immunoglobulins, the ketogenic diet, and surgery. Maybe therapy targeted mechanisms can be developed with deep insight into the etiology of ESES.

中文翻译：

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缓慢睡眠期间与癫痫持续状态相关的脑病的治疗策略，文献叙述性回顾。

与缓慢睡眠期间癫痫持续状态 (ESES) 相关的脑病是一种年龄依赖性综合征，其特征是出现与睡眠期间癫痫活动极度激活相关的神经心理和行为障碍。ESES 治疗的主要目标是预防神经心理缺陷。减少癫痫发作和解决睡眠期间癫痫持续状态 (SES) 的 EEG 模式的有效治疗可能对改善长期预后至关重要。然而，是否通过抑制或消除 SES 来改善神经发育缺陷仍然未知。本文的目的是回顾 ESES 中当前的治疗方案，以提供更好的替代方案。治疗选择包括抗癫痫药物、类固醇、免疫球蛋白、生酮饮食和手术。