Application of a novel thermo‐sensitive injectable hydrogel in therapy in situ for drug accurate controlled release,Journal of Biomedical Materials Research Part B: Applied Biomaterials

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Application of a novel thermo‐sensitive injectable hydrogel in therapy in situ for drug accurate controlled release
Journal of Biomedical Materials Research Part B: Applied Biomaterials ( IF 3.2 ) Pub Date : 2020-07-17 , DOI: 10.1002/jbm.b.34658
Xiaoying Kong ₁ , Ruizhi Houzong ₁ , Jun Fu ₂ , Kai Shao ₃ , Lili Wang ₄ , Yongchao Ma ₁ , Jinsheng Shi ₁

Affiliation

Local drug injection therapy for tumor site, as a neoadjuvant chemotherapy method, shows important significance in clinical application; however, it obtains unsatisfying therapeutic effect due to the serious toxic and side effect in normal tissues caused by drug diffusion or complexity of the preparation. In this article, the influence factors of the gelling time of traditional Chitosan (CTS) thermo‐sensitive hydrogels were analyzed, and the gelling properties were improved significantly, and a thermo‐sensitive hydrogel with precisely regulated gelling time was obtained through a green and simple preparation method, and the shortest gelling time (gelling time = 27 ± 2 s) of this hydrogel was 5% of that of the common CTS thermo‐sensitive hydrogels. After loaded with different chemotherapy drugs with different pH values (gemctiabin hydrochloride, levofloxacin, and 5‐foluorouracil), the hydrogels' gelling performance was not affected, while the gelling time could be shortened by 5‐foluorouracil, effectively hindering the drug loss at the early stage of sustained release. in vitro and in vivo experiments proved that precise encapsulation toward tumors with different volumes was achieved by the hydrogels, with minimal damage to surrounding normal tissues and higher utilization of drugs in tumor sites, ultimately achieving better tumor therapeutic effect. In conclusion, the new thermo‐sensitive hydrogels with precisely regulated gelling time showed great significance and potential for drug delivery and neoadjuvant chemotherapy.

中文翻译：

一种新型热敏可注射水凝胶在药物原位精确控释中的应用

肿瘤部位局部药物注射疗法作为一种新辅助化疗方法，在临床应用中具有重要意义；但由于药物扩散或制剂复杂，对正常组织毒副作用严重，治疗效果不尽如人意。本文分析了传统壳聚糖（CTS）热敏水凝胶凝胶时间的影响因素，凝胶性能显着提高，通过绿色、简单的方法获得了凝胶时间精确调控的热敏水凝胶。该水凝胶的最短凝胶时间（凝胶时间 = 27±2 s）是普通 CTS 热敏水凝胶的 5%。装入不同pH值的不同化疗药物（盐酸吉姆西滨、左氧氟沙星和5-氟尿嘧啶），水凝胶的胶凝性能不受影响，而5-氟尿嘧啶可缩短胶凝时间，有效阻止药物在缓释早期的损失。体外和体内实验证明，水凝胶实现了对不同体积肿瘤的精确包封，对周围正常组织的损伤最小，肿瘤部位的药物利用率更高，最终达到更好的肿瘤治疗效果。总之，具有精确调节胶凝时间的新型热敏水凝胶在药物递送和新辅助化疗方面具有重要意义和潜力。有效阻止药物在缓释初期的流失。体外和体内实验证明，水凝胶实现了对不同体积肿瘤的精确包封，对周围正常组织的损伤最小，肿瘤部位的药物利用率更高，最终达到更好的肿瘤治疗效果。总之，具有精确调节胶凝时间的新型热敏水凝胶在药物递送和新辅助化疗方面具有重要意义和潜力。有效阻止药物在缓释初期的流失。体外和体内实验证明，水凝胶实现了对不同体积肿瘤的精确包封，对周围正常组织的损伤最小，肿瘤部位的药物利用率更高，最终达到更好的肿瘤治疗效果。总之，具有精确调节胶凝时间的新型热敏水凝胶在药物递送和新辅助化疗方面具有重要意义和潜力。最终达到更好的肿瘤治疗效果。总之，具有精确调节胶凝时间的新型热敏水凝胶在药物递送和新辅助化疗方面具有重要意义和潜力。最终达到更好的肿瘤治疗效果。总之，具有精确调节胶凝时间的新型热敏水凝胶在药物递送和新辅助化疗方面具有重要意义和潜力。

更新日期：2020-07-17

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