Direct visualization and characterization of the human zona incerta and surrounding structures.,Human Brain Mapping

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Direct visualization and characterization of the human zona incerta and surrounding structures.
Human Brain Mapping ( IF 3.5 ) Pub Date : 2020-07-17 , DOI: 10.1002/hbm.25137
Jonathan C Lau _{1,

2,

3,

4} , Yiming Xiao _{2,

3} , Roy A M Haast _{2,

3} , Greydon Gilmore _{1,

4} , Kâmil Uludağ _{5,

6,

7} , Keith W MacDougall ₁ , Ravi S Menon _{2,

3,

8} , Andrew G Parrent ₁ , Terry M Peters _{1,

2,

3,

4,

8} , Ali R Khan _{1,

2,

3,

4,

8,

9}

Affiliation

The zona incerta (ZI) is a small gray matter region of the deep brain first identified in the 19th century, yet direct in vivo visualization and characterization has remained elusive. Noninvasive detection of the ZI and surrounding region could be critical to further our understanding of this widely connected but poorly understood deep brain region and could contribute to the development and optimization of neuromodulatory therapies. We demonstrate that high resolution (submillimetric) longitudinal (T1) relaxometry measurements at high magnetic field strength (7 T) can be used to delineate the ZI from surrounding white matter structures, specifically the fasciculus cerebellothalamicus, fields of Forel (fasciculus lenticularis, fasciculus thalamicus, and field H), and medial lemniscus. Using this approach, we successfully derived in vivo estimates of the size, shape, location, and tissue characteristics of substructures in the ZI region, confirming observations only previously possible through histological evaluation that this region is not just a space between structures but contains distinct morphological entities that should be considered separately. Our findings pave the way for increasingly detailed in vivo study and provide a structural foundation for precise functional and neuromodulatory investigation.

中文翻译：

人类不确定带和周围结构的直接可视化和表征。

不确定带 (ZI) 是 19 世纪首次发现的深部大脑的一个小灰质区域，但直接的体内可视化和表征仍然难以捉摸。ZI 和周围区域的无创检测对于进一步了解这个广泛连接但知之甚少的大脑深部区域至关重要，并可能有助于神经调节疗法的开发和优化。我们证明了在高磁场强度 (7 T) 下的高分辨率（亚毫米）纵向 (T1) 弛豫测量可用于从周围的白质结构中描绘 ZI，特别是小脑束、Forel 场（豆束、丘脑束） , 和字段 H), 和内侧丘系。使用这种方法，我们成功地推导出了 ZI 区域子结构的大小、形状、位置和组织特征的体内估计，证实了以前只能通过组织学评估才能观察到的观察结果，即该区域不仅是结构之间的空间，还包含不同的形态实体，这些实体应该是分开考虑。我们的发现为越来越详细的体内研究铺平了道路，并为精确的功能和神经调节研究提供了结构基础。

更新日期：2020-07-17

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