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Aberrant frontostriatal connectivity in Alzheimer's disease with positive palmomental reflex.
European Journal of Neurology ( IF 4.5 ) Pub Date : 2020-07-17 , DOI: 10.1111/ene.14443
H Gramespacher 1 , N Richter 1, 2 , S Edwin Thanarajah 1, 3, 4 , H I L Jacobs 5, 6 , K N H Dillen 2, 7 , N Nellessen 1 , B von Reutern 1, 2 , J Dronse 1, 2 , J Kukolja 1, 8, 9 , G R Fink 1, 2 , O A Onur 1, 2
Affiliation  

Primitive reflexes may reoccur in various neurodegenerative diseases. However, little is known about their structural and functional correlates in the human brain. Notably, the neural mechanisms underlying a positive palmomental reflex (PMR) are poorly understood. As recent studies link Alzheimer's disease (AD)‐related primitive reflexes to a dysfunction of the corticostriatal motor circuit (CMC), we conducted the present study to investigate functional and structural correlates of a positive PMR. We hypothesized an involvement of frontostriatal structures and an impairment of the CMC.

中文翻译:

掌膜反射阳性的阿尔茨海默氏病的前额窦异常连接。

原始反射可能会在各种神经退行性疾病中再次发生。但是,关于它们在人脑中的结构和功能相关性知之甚少。值得注意的是,对正手掌反射(PMR)的神经机制了解甚少。由于最近的研究将阿尔茨海默氏病(AD)相关的原始反射与皮层运动功能障碍(CMC)相关联,我们进行了本研究以研究阳性PMR的功能和结构相关性。我们假设涉及额骨结构和CMC的损害。
更新日期:2020-07-17
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