Enzymatic Construction of Artificial Base Pairs: The Effect of Metal Shielding.,ChemBioChem

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Enzymatic Construction of Artificial Base Pairs: The Effect of Metal Shielding.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-07-16 , DOI: 10.1002/cbic.202000402
Marie Flamme _{1,

2,

3} , Fabienne Levi-Acobas ₁ , Susanne Hensel ₄ , Shuvankar Naskar ₄ , Pascal Röthlisberger ₁ , Ivo Sarac ₁ , Gilles Gasser ₃ , Jens Müller ₄ , Marcel Hollenstein ₁

Affiliation

A, C, G, T… Ag, Cr: We have explored using nucleotides bearing methylated imidazole base surrogates to expand the genetic alphabet with artificial metal base pairs. This methylation pattern improves silver‐mediated base pair formation compared to the unmodified imidiazole nucleotide. We extended this approach to underexplored metal ions and observed the formation of a chromium‐mediated metal base pair.

中文翻译：

人工碱基对的酶促构建：金属屏蔽作用。

A，C，G，T…Ag，Cr：我们已经探索了使用带有甲基化咪唑碱基替代物的核苷酸来扩展带有人工金属碱基对的遗传字母。与未修饰的咪唑核苷酸相比，这种甲基化模式改善了银介导的碱基对的形成。我们将这种方法扩展至未充分利用的金属离子，并观察到了铬介导的金属碱基对的形成。

更新日期：2020-07-16

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