Tryptophan Synthase: Biocatalyst Extraordinaire.,ChemBioChem

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Tryptophan Synthase: Biocatalyst Extraordinaire.
ChemBioChem ( IF 2.6 ) Pub Date : 2020-07-16 , DOI: 10.1002/cbic.202000379
Ella Watkins-Dulaney ₁ , Sabine Straathof ₂ , Frances Arnold _{1,

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Affiliation

Multifunctional: Tryptophan synthase (TrpS) natively catalyzes the formation of tryptophan but also possesses remarkable promiscuous activity for synthesizing a wide range of noncanonical amino acids (ncAAs). This review looks at TrpS as a ncAA synthase, from the characterization of its broad substrate scope via efforts to expand its non‐natural chemistry to applications in synthesizing diverse natural and xenobiotic compounds.