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Calcium Phosphate Mineralized Black Phosphorous with Enhanced Functionality and Anticancer Bioactivity
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-07-16 , DOI: 10.1002/adfm.202003069 Ting Pan 1, 2 , Wen Fu 1, 3 , Hongbao Xin 2 , Shengyong Geng 1 , Zhibin Li 1 , Haodong Cui 1, 3 , Yanli Zhang 1 , Paul K. Chu 4 , Wenhua Zhou 1 , Xue‐Feng Yu 1
Advanced Functional Materials ( IF 18.5 ) Pub Date : 2020-07-16 , DOI: 10.1002/adfm.202003069 Ting Pan 1, 2 , Wen Fu 1, 3 , Hongbao Xin 2 , Shengyong Geng 1 , Zhibin Li 1 , Haodong Cui 1, 3 , Yanli Zhang 1 , Paul K. Chu 4 , Wenhua Zhou 1 , Xue‐Feng Yu 1
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Biodegradable inorganic nanomaterials have opened new perspectives for cancer therapy due to their inherent anticancer activity. Black phosphorus nanosheets (BPs) with their unique bioactivity have recently been identified as promising cancer therapeutic agents but their application is hampered by the difficulty in surface functionalization. Herein, an in situ calcium phosphate (CaP) mineralization strategy is described to enhance the anticancer activity of BPs. By using BPs as the phosphate sources and growth templates, the synthesized CaP‐mineralized BPs (CaBPs) retain the intrinsic properties of BPs and at the same time have high loading capacities for various fluorophores to enable effective bioimaging and tracing. Compared to BPs, CaBPs exhibit enhanced and selective anticancer bioactivity due to the improved pH‐responsive degradation behavior and intracellular Ca2+ overloading in cancer cells. Furthermore, CaBPs specifically target mitochondria and cause structural damage, thus leading to mitochondria‐mediated apoptosis in cancer cells. After intravenous injection, CaBPs target orthotopic breast cancer cells to inhibit tumor growth without giving rise to adverse effects or toxicity. The results demonstrate the great potential of CaBPs as targeted anticancer agents and the CaP mineralization approach provides a versatile surface functionalization strategy for nanotherapeutic agents.
中文翻译：
磷酸钙矿化黑磷具有增强的功能和抗癌生物活性
可生物降解的无机纳米材料因其固有的抗癌活性而为癌症治疗开辟了新的前景。黑磷纳米片（BPs）具有独特的生物活性，最近已被确认为有前途的癌症治疗剂，但由于表面功能化的困难而使其应用受到阻碍。在本文中，描述了原位磷酸钙（CaP）矿化策略以增强BPs的抗癌活性。通过使用BP作为磷酸盐来源和生长模板，合成的CaP矿化BP（CaBP）保留了BP的固有特性，同时具有对各种荧光团的高负载能力，从而能够进行有效的生物成像和示踪。与BP相比，2+癌细胞超负荷。此外，CaBPs特异性靶向线粒体并引起结构破坏，从而导致癌细胞中线粒体介导的细胞凋亡。静脉注射后，CaBPs靶向原位乳腺癌细胞以抑制肿瘤生长，而不会产生不利影响或毒性。结果表明，CaBPs作为靶向抗癌剂具有巨大潜力，并且CaP矿化方法为纳米治疗剂提供了一种通用的表面功能化策略。
更新日期：2020-09-18
中文翻译：
磷酸钙矿化黑磷具有增强的功能和抗癌生物活性
可生物降解的无机纳米材料因其固有的抗癌活性而为癌症治疗开辟了新的前景。黑磷纳米片（BPs）具有独特的生物活性，最近已被确认为有前途的癌症治疗剂，但由于表面功能化的困难而使其应用受到阻碍。在本文中，描述了原位磷酸钙（CaP）矿化策略以增强BPs的抗癌活性。通过使用BP作为磷酸盐来源和生长模板，合成的CaP矿化BP（CaBP）保留了BP的固有特性，同时具有对各种荧光团的高负载能力，从而能够进行有效的生物成像和示踪。与BP相比，2+癌细胞超负荷。此外，CaBPs特异性靶向线粒体并引起结构破坏，从而导致癌细胞中线粒体介导的细胞凋亡。静脉注射后，CaBPs靶向原位乳腺癌细胞以抑制肿瘤生长，而不会产生不利影响或毒性。结果表明，CaBPs作为靶向抗癌剂具有巨大潜力，并且CaP矿化方法为纳米治疗剂提供了一种通用的表面功能化策略。
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