Dendritic cells (DCs) are sentinel cells of the immune system arising from hematopoietic stem cells. DCs play a key role in the regulation of both adaptive and innate lymphocyte responses. As such, experimental models enabling a thorough analysis of human DCs development and function are needed. Humanized mice models (termed collectively as HIS mice, or human immune system mice models) provide unique opportunities to model human hematopoiesis and tackle the function of human immune cell types in vivo. Here, we review experimental approaches enabling to recapitulate the ontogeny of DC subsets in HIS mice and discuss studies addressing the biology of human DC subsets implementing HIS mice models.

树突状细胞（DC）是造血干细胞产生的免疫系统前哨细胞。DC在适应性和先天性淋巴细胞应答的调节中起关键作用。因此，需要能够对人类DC的发展和功能进行全面分析的实验模型。人源化小鼠模型（统称为HIS小鼠或人类免疫系统小鼠模型）提供了建模人类造血功能和解决体内人类免疫细胞类型功能的独特机会。在这里，我们回顾了能够概述HIS小鼠DC子集的个体存在的实验方法，并讨论了解决实现HIS小鼠模型的人类DC子集的生物学研究。