Moringa oleifera L. (MO), known for its nutritional and medicinal value, has strong anti-proliferative effects on various types of cancer. The objective of this study was to evaluate the antioxidant and anti-proliferative properties of MO extracts using head and neck cancer (HNC) cell lines, CNE-1 and CAL27. Sixteen MO extracts from seeds, roots, stems, and leaves were prepared with water and different concentration of ethanol (50, 70 and 90%). Total phenolic and flavonoid contents (TPC, TFC) and the antioxidant activity of these extracts were analyzed. The results showed that the aqueous extracts (MOL) had the highest antioxidant activities in leaf, while 70% ethanol extracts (MOS, MOR, MOSt) had the highest antioxidant values in other parts (seeds, roots, and stems). Furthermore, all MO extracts had significant anti-cancer effects on HNC cells. The corresponding IC₅₀ values of MOSt, MOL, MOR, MOS were 0.135, 0.298, 1.07, and 1.10 mg/mL in CNE-1 cells and 0.163, 0.251, 1.19, and 1.22 mg/mL in CAL27 cells, respectively. MO extracts inhibited the proliferation of HNC cells by inducing apoptosis. Particularly, MOSt had the strongest apoptotic induction, followed by MOL. These results indicated that MO extracts have a potential antioxidant capacity and may be beneficial for the prevention and treatment of HNC.

辣木L.（MO）以营养和药用价值着称，对各种类型的癌症均具有强大的抗增殖作用。这项研究的目的是评估使用头颈癌（HNC）细胞系CNE-1和CAL27的MO提取物的抗氧化和抗增殖特性。用水和不同浓度的乙醇（50％，70％和90％）制备从种子，根，茎和叶的16种MO提取物。分析了这些提取物的总酚和类黄酮含量（TPC，TFC）和抗氧化活性。结果表明，水提取物（MOL）在叶片中的抗氧化活性最高，而70％乙醇提取物（MOS，MOR，MOSt）在其他部位（种子，根和茎）的抗氧化性最高。此外，所有MO提取物均对HNC细胞具有显着的抗癌作用。在CNE-1细胞中，MOSt，MOL，MOR，MOS的_50个值分别为0.135、0.298、1.07和1.10 mg / mL，在CAL27细胞中分别为0.163、0.251、1.19和1.22 mg / mL。MO提取物通过诱导凋亡来抑制HNC细胞的增殖。特别是，MOSt具有最强的凋亡诱导作用，其次是MOL。这些结果表明，MO提取物具有潜在的抗氧化能力，可能对HNC的预防和治疗有益。