The dynamical response of oleic acid (OA), oleic acid/2, 3-dimercaptosuccinic acid (OA/DMSA) and oleic/citric acid (OA/CA) coated iron oxide (Fe₃O₄) nanoparticles in water and phosphate buffer saline (pH = 7) is investigated by dynamic light scattering (DLS). The aggregation and fragmentation rate of suspended nanoparticles at different concentration of buffers is evaluated. Iron oxide nanoparticles coated with OA, OA/DMSA and OA/CA are synthesized via thermal decomposition and ligand exchange wet chemical route. The hydrodynamic spherical diameter of OA, OA/DMSA and OA/CA coated nanoparticles, measured at room temperature are found to be 83.6, 133.7 and 147.7 nm. The formation of clusters and their distribution in the magnetic nanoparticles suspension is obtained from DLS experiments. It is correlated with the theoretical model based on diffusion dominated aggregation model. The growth rate β due to tailored aggregation and fragmentation processes at different volume fractions in different solvents, shows power law dependence as <k(t) > ~t^βat intermediate time scale. The slope β for OA/DMSA and OA/CA coated MNPs is obtained to be 0.09 and 0.1 respectively. These studies are therefore extremely relevant and can provide guidelines for research in biological fluids such as serum, plasma etc.

油酸（OA），油酸/ 2、3-二巯基琥珀酸（OA / DMSA）和油酸/柠檬酸（OA / CA）涂覆的氧化铁（Fe ₃ O ₄通过动态光散射（DLS）研究了水和磷酸盐缓冲盐水（pH = 7）中的纳米颗粒。评价了不同浓度的缓冲液中悬浮的纳米颗粒的聚集和破碎速率。通过热分解和配体交换湿化学途径合成了包覆有OA，OA / DMSA和OA / CA的氧化铁纳米粒子。发现在室温下测量的OA，OA / DMSA和OA / CA涂覆的纳米颗粒的流体动力学球形直径为83.6、133.7和147.7 nm。团簇的形成及其在磁性纳米颗粒悬浮液中的分布是通过DLS实验获得的。它与基于扩散支配聚集模型的理论模型相关。ķ（吨）>〜吨^β在中间的时间尺度。OA / DMSA和OA / CA包被的MNP的斜率β分别为0.09和0.1。因此，这些研究非常相关，可以为研究诸如血清，血浆等生物液体提供指导。