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Getting intimate: Lysosomes and ER rendezvous to control autophagy.
Cell Calcium ( IF 4 ) Pub Date : 2020-07-17 , DOI: 10.1016/j.ceca.2020.102249
Philippe Pihán 1 , Claudio Hetz 2
Affiliation  

The endoplasmic reticulum (ER) is the source of lysosomal calcium. The finding that the protein TMBIM6 –a putative ER calcium channel and cell death regulator –promotes calcium transfer from the ER to lysosomes to induce autophagy uncovers a missing piece in the puzzle of inter-organelle communication.



中文翻译:

亲密:溶酶体和内质网会合以控制自噬。

内质网 (ER) 是溶酶体钙的来源。蛋白质 TMBIM6——一种假定的内质网钙通道和细胞死亡调节剂——促进钙从内质网转移到溶酶体以诱导自噬的发现揭示了细胞器间通讯难题中的一个缺失部分。

更新日期:2020-07-22
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