当前位置: X-MOL 学术Alex. Eng. J. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Controlled drug delivery using the magnetic nanoparticles in non-Newtonian blood vessels
Alexandria Engineering Journal ( IF 6.2 ) Pub Date : 2020-07-16 , DOI: 10.1016/j.aej.2020.07.010
Nidal H. Abu-Hamdeh , Rashad A.R. Bantan , Farhad Aalizadeh , Ashkan Alimoradi

Fouling in blood flow is very common and may decrease the blood flow in human body and lead to critical health issues. Upon injury in a blood vessel, the body’s defensive system triggers a process to create a blood clot called “Thrombus”, which prevents bleeding. Blood clots are formed by a combination of blood cells, platelets, and fibrins. In this study, we investigate a controlled drug delivery using the magnetic nanoparticles in blood vessels under the influence of magnetic fields. For this purpose the Maxwell and the Navier-Stokes equations for the system are solved. In contrary to the previous studies it is assumed that the blood is a non-Newtonian fluid. The number of particles has been considered large enough to gain statistically robust results and the effects of various parameters on the settlement of nanoparticles on the surface of a bump in the blood vessel by the magnetic field is inspected. It is revealed that considering non-Newtonian characteristics is essential in modeling such systems and the results may be very different from those obtained by assuming the blood as a Newtonian fluid. Also, it is found that the magnetic field intensity and the magnetic field permeability coefficient have important effects on the settlement of nanoparticles.



中文翻译:

使用非牛顿血管中的磁性纳米粒子控制药物的输送

血流中的污垢非常普遍,可能会减少人体中的血流并导致严重的健康问题。一旦血管受伤,人体的防御系统就会触发一个过程,形成一个称为“血栓”的血块,以防止出血。血块是由血细胞,血小板和纤维蛋白的组合形成的。在这项研究中,我们研究了在磁场的影响下使用血管中磁性纳米颗粒的受控药物递送。为此,求解了系统的麦克斯韦方程和纳维尔-斯托克斯方程。与先前的研究相反,假定血液是非牛顿流体。已经认为颗粒的数量足够大以获得统计上可靠的结果,并且检查了各种参数对通过磁场在血管的隆起表面上的纳米颗粒的沉降的影响。结果表明,在这种系统的建模中必须考虑非牛顿特性,其结果可能与假设血液为牛顿流体而获得的结果大不相同。而且,发现磁场强度和磁场渗透系数对纳米颗粒的沉降具有重要影响。结果表明,在这种系统的建模中必须考虑非牛顿特性,其结果可能与假设血液为牛顿流体而获得的结果大不相同。而且,发现磁场强度和磁场渗透系数对纳米颗粒的沉降具有重要影响。结果表明,在这种系统的建模中必须考虑非牛顿特性,其结果可能与假设血液为牛顿流体而获得的结果大不相同。而且,发现磁场强度和磁场渗透系数对纳米颗粒的沉降具有重要影响。

更新日期:2020-07-17
down
wechat
bug