Four-repeat tauopathies are a neurodegenerative disease characterized by brain parenchymal accumulation of a specific isoform of the protein tau, which gives rise to a wide breadth of clinical syndromes encompassing diverse symptomatology, with the most common syndromes being progressive supranuclear palsy-Richardson’s and corticobasal syndrome. Despite the lack of effective disease-modifying therapies, targeted treatment of symptoms can improve quality of life for patients with 4-repeat tauopathies. However, managing these symptoms can be a daunting task, even for those familiar with the diseases, as they span motor, sensory, cognitive, affective, autonomic, and behavioral domains. This review describes current approaches to symptomatic management of common clinical symptoms in 4-repeat tauopathies with a focus on practical patient management, including pharmacologic and nonpharmacologic strategies, and concludes with a discussion of the history and future of disease-modifying therapeutics and clinical trials in this population.

四重复 tau 病是一种神经退行性疾病，其特征是特定 tau 蛋白亚型在脑实质内积聚，可引起多种临床综合征，涵盖多种症状，最常见的综合征是进行性核上性麻痹 - 理查德森综合征和皮质基底节综合征。尽管缺乏有效的疾病缓解疗法，但针对症状的针对性治疗可以改善 4 次重复 tau蛋白病患者的生活质量。然而，即使对于熟悉这些疾病的人来说，控制这些症状也可能是一项艰巨的任务，因为它们跨越运动、感觉、认知、情感、自主和行为领域。这篇综述描述了目前对 4 次重复 tau蛋白病常见临床症状进行症状管理的方法，重点是实际的患者管理，包括药物和非药物策略，最​​后讨论了疾病缓解疗法和临床试验的历史和未来。这个人口。