An efficient, transition-metal-free method to synthesize dihydroisobenzofuran derivatives via intramolecular hydroalkoxylation of aromatic alkynols with the promotion of cesium carbonate has been developed. The reaction proceeds regioselectively with exclusive formation of 5-exo-dig product, and only Z-isomer of the new generated double bond is observed. This new protocol features with milder reaction conditions, more convenient operation and satisfactory selectivities.

中文翻译：

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芳香炔烃的区域和立体选择性分子内氢烷氧基化：在无过渡金属的条件下获得二氢异苯并呋喃

已经开发了一种有效的，无过渡金属的方法，该方法通过芳香族炔醇的分子内加氢烷氧基化并促进碳酸铯来合成二氢异苯并呋喃衍生物。该反应在区域选择性地进行，仅形成5-exo-dig产物，并且仅观察到新产生的双键的Z-异构体。该新方案具有较温和的反应条件，更方便的操作和令人满意的选择性。