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Comment on Saber et al. (2019), "Commentary: the chronic inhalation study in rats for assessing lung cancer risk may be better than its reputation".
Particle and Fibre Toxicology ( IF 7.2 ) Pub Date : 2020-07-16 , DOI: 10.1186/s12989-020-00365-z
Kevin E Driscoll 1 , Paul A Borm 2, 3 , Ishrat Chaudhuri 4 , Len Levy 5 , Mei Yong 6 , David Warheit 7 , Robert McCunney 8 , Günter Oberdörster 9
Affiliation  

In their Commentary Saber et al. (Part Fibre Toxicol 16: 44, 2019) argue that chronic inhalation studies in rats can be used for assessing the lung cancer risk of insoluble nanomaterials. The authors make several significant errors in their interpretation and representation of the underlying science. In this Letter to the Editor we discuss these inaccuracies to correct the scientific record. When the science is recounted accurately it does not support Saber et al’s statements and conclusions.

中文翻译:


对 Saber 等人的评论(2019),“评论:用于评估肺癌风险的大鼠慢性吸入研究可能比其声誉更好”。



在 Saber 等人的评论中。 (Part Fiber Toxicol 16: 44, 2019) 认为,大鼠慢性吸入研究可用于评估不溶性纳米材料的肺癌风险。作者在对基础科学的解释和表述中犯了几个重大错误。在这封致编辑的信中,我们讨论这些不准确之处以纠正科学记录。当科学被准确地叙述时,它并不支持 Saber 等人的陈述和结论。
更新日期:2020-07-16
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