The complexity of the blood–brain barrier (BBB) and neurovascular unit (NVU) was and still is a challenge to bridge. A highly selective, restrictive and dynamic barrier, formed at the interface of blood and brain, the BBB is a “gatekeeper” and guardian of brain homeostasis and it also acts as a “sensor” of pathological events in blood and brain. The majority of brain and cerebrovascular pathologies are associated with BBB dysfunction, where changes at the BBB can lead to or support disease development. Thus, an ultimate goal of BBB research is to develop competent and highly translational models to understand mechanisms of BBB/NVU pathology and enable discovery and development of therapeutic strategies to improve vascular health and for the efficient delivery of drugs. This review article focuses on the progress being made to model BBB injury in cerebrovascular diseases in vitro.

中文翻译：

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体外模拟脑血管疾病的血脑屏障病理学：当前和未来的范例


血脑屏障（BBB）和神经血管单元（NVU）的复杂性过去和现在仍然是一个需要克服的挑战。血脑屏障是形成于血液和大脑界面的高度选择性、限制性和动态屏障，是大脑稳态的“看门人”和守护者，也是血液和大脑病理事件的“传感器”。大多数大脑和脑血管病变与 BBB 功能障碍有关，其中 BBB 的变化可能导致或支持疾病的发展。因此，BBB 研究的最终目标是开发有效且高度转化的模型，以了解 BBB/NVU 病理机制，并能够发现和开发治疗策略，以改善血管健康和有效输送药物。本文重点介绍脑血管疾病中 BBB 损伤体外模型的进展。