Background. Despite progress made in understanding functional reorganization patterns underlying recovery in subacute aphasia, the relation between recovery and changes in white matter structure remains unclear. Objective. To investigate changes in dorsal and ventral language white matter tract integrity in relation to naming recovery in subacute poststroke aphasia. Methods. Ten participants with aphasia after left-hemisphere stroke underwent language testing and diffusion tensor imaging twice within 3 months post onset, with a 1-month interval between sessions. Deterministic tractography was used to bilaterally reconstruct the superior longitudinal fasciculus (SLF), inferior fronto-occipital fasciculus (IFOF), inferior longitudinal fasciculus (ILF), middle longitudinal fasciculus (MdLF), and uncinate fasciculus (UF). Per tract, the mean fractional anisotropy (FA) was extracted as a measure of microstructural integrity. Naming accuracy was assessed with the Boston Naming Test (BNT). Correlational analyses were performed to investigate the relationship between changes in FA values and change in BNT score. Results. A strong positive correlation was found between FA change in the right ILF within the ventral stream and change on the BNT (r = 0.91, P < .001). An increase in FA in the right ILF was associated with considerable improvement of naming accuracy (range BNT change score: 12-14), a reduction with limited improvement or slight deterioration. No significant correlations were found between change in naming accuracy and FA change in any of the other right or left ventral and dorsal language tracts. Conclusions. Naming recovery in subacute aphasia is associated with change in the integrity of the right ILF.

中文翻译：

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右下纵束完整性的变化与亚急性卒中后失语症的命名恢复有关

背景。尽管在理解亚急性失语症恢复的功能重组模式方面取得了进展，但恢复与白质结构变化之间的关系仍不清楚。目标。研究与亚急性卒中后失语症命名恢复相关的背侧和腹侧语言白质束完整性的变化。方法。10 名左半球卒中后失语的参与者在发病后 3 个月内接受了两次语言测试和弥散张量成像，两次会议之间的间隔为 1 个月。确定性纤维束成像用于双侧重建上纵束 (SLF)、下额枕束 (IFOF)、下纵束 (ILF)、中纵束 (MdLF) 和钩状束 (UF)。每道，提取平均分数各向异性 (FA) 作为微观结构完整性的衡量标准。命名准确性通过波士顿命名测试 (BNT) 进行评估。进行相关分析以研究 FA 值变化与 BNT 评分变化之间的关系。结果。腹侧流内右侧 ILF 的 FA 变化与 BNT 的变化之间存在强正相关（r = 0.91，P < .001）。右侧 ILF 中 FA 的增加与命名准确性的显着提高有关（范围 BNT 变化评分：12-14），减少但改善有限或略有恶化。在任何其他右或左腹侧和背侧语言束中，命名准确性的变化与 FA 变化之间没有发现显着相关性。结论。