Background. In recent years, there is growing literature on the prognostic significance of programmed death-ligand 1 (PD-L1) in cholangiocarcinoma (CCA); however, data have been conflicting. Therefore, the objective of this study was to assess the correlation between PD-L1 and prognosis in CCA through meta-analysis. Methods. Published studies were retrieved from the Web of Science, PubMed, Embase, and Cochrane Library up to April 17, 2020. The relationships between PD-L1 expression and survival outcomes were assessed using hazard ratios (HRs) and 95% confidence intervals (CIs). Results. Eighteen studies consisting of 2012 patients were included. Overexpression of PD-L1 was significantly associated with worse overall survival (OS) (, , ) but not with poor disease-free survival (DFS) (, , ) in CCA. Moreover, PD-L1 was associated with low differentiation (, , ) and higher pN stage (, , ) but not with sex, TNM stage, vascular invasion, perineural invasion, age, or tumor size. Conclusion. High PD-L1 expression was associated with worse OS, poor differentiation, and higher pN stage in patients with CCA. PD-L1 could be a potential prognostic marker in CCA.

中文翻译：

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PD-L1在胆管癌患者中的预后和临床病理学意义：一项荟萃分析。

背景。近年来，关于程序性死亡配体 1 (PD-L1) 在胆管癌 (CCA) 中的预后意义的文献越来越多。然而，数据一直相互矛盾。因此，本研究的目的是通过荟萃分析评估 PD-L1 与 CCA 预后之间的相关性。方法。截至 2020 年 4 月 17 日，已从 Web of Science、PubMed、Embase 和 Cochrane 图书馆检索已发表的研究。使用风险比 (HR) 和 95% 置信区间 (CI) 评估 PD-L1 表达与生存结果之间的关系. 结果。纳入了由 2012 名患者组成的 18 项研究。PD-L1 的过表达与较差的总生存期 (OS) 显着相关（, , )但无病生存期 (DFS) 较差 (, , )在 CCA 中。此外，PD-L1 与低分化相关（, , )和更高的 pN 阶段 (, , )但与性别、TNM 分期、血管侵犯、神经周围侵犯、年龄或肿瘤大小无关。结论。高 PD-L1 表达与 CCA 患者较差的 OS、较差的分化和较高的 pN 分期相关。PD-L1 可能是 CCA 的潜在预后标志物。