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DNA Functional Materials Assembled from Branched DNA: Design, Synthesis, and Applications.
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-07-16 , DOI: 10.1021/acs.chemrev.0c00294 Yuhang Dong 1 , Chi Yao 1 , Yi Zhu 1 , Lu Yang 1 , Dan Luo 2 , Dayong Yang 1
Chemical Reviews ( IF 51.4 ) Pub Date : 2020-07-16 , DOI: 10.1021/acs.chemrev.0c00294 Yuhang Dong 1 , Chi Yao 1 , Yi Zhu 1 , Lu Yang 1 , Dan Luo 2 , Dayong Yang 1
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DNA is traditionally known as a central genetic biomolecule in living systems. From an alternative perspective, DNA is a versatile molecular building-block for the construction of functional materials, in particular biomaterials, due to its intrinsic biological attributes, molecular recognition capability, sequence programmability, and biocompatibility. The topologies of DNA building-blocks mainly include linear, circular, and branched types. Branched DNA recently has been extensively employed as a versatile building-block to synthesize new biomaterials, and an assortment of promising applications have been explored. In this review, we discuss the progress on DNA functional materials assembled from branched DNA. We first briefly introduce the background information on DNA molecules and sketch the development history of DNA functional materials constructed from branched DNA. In the second part, the synthetic strategies of branched DNA as building-blocks are categorized into base-pairing assembly and chemical bonding. In the third part, construction strategies for the branched DNA-based functional materials are comprehensively summarized including tile-mediated assembly, DNA origami, dynamic assembly, and hybrid assembly. In the fourth part, applications including diagnostics, protein engineering, drug and gene delivery, therapeutics, and cell engineering are demonstrated. In the end, an insight into the challenges and future perspectives is provided. We envision that branched DNA functional materials can not only enrich the DNA nanotechnology by ingenious design and synthesis but also promote the development of interdisciplinary fields in chemistry, biology, medicine, and engineering, ultimately addressing the growing demands on biological and medical-related applications in the real world.
中文翻译：
从支链DNA组装的DNA功能材料：设计，合成和应用。
传统上，DNA被称为生命系统中的核心遗传生物分子。从另一个角度来看，由于其固有的生物学特性，分子识别能力，序列可编程性和生物相容性，DNA是用于构建功能性材料（尤其是生物材料）的通用分子构件。DNA构件的拓扑主要包括线性，圆形和分支类型。最近，支链DNA被广泛用作合成新生物材料的通用构建基块，并且已经探索了各种有前途的应用。在这篇综述中，我们讨论了由分支DNA组装而成的DNA功能材料的进展。我们首先简要介绍有关DNA分子的背景信息，并概述由分支DNA构成的DNA功能材料的发展历史。在第二部分中，将分支DNA作为构建基块的合成策略分为碱基配对组装和化学键合。在第三部分中，对基于支链DNA的功能材料的构建策略进行了全面总结，包括平铺介导的组装，DNA折纸，动态组装和混合组装。在第四部分中，演示了应用程序，包括诊断，蛋白质工程，药物和基因传递，治疗和细胞工程。最后，提供了对挑战和未来前景的见解。
更新日期：2020-09-10
中文翻译：
从支链DNA组装的DNA功能材料：设计，合成和应用。
传统上，DNA被称为生命系统中的核心遗传生物分子。从另一个角度来看，由于其固有的生物学特性，分子识别能力，序列可编程性和生物相容性，DNA是用于构建功能性材料（尤其是生物材料）的通用分子构件。DNA构件的拓扑主要包括线性，圆形和分支类型。最近，支链DNA被广泛用作合成新生物材料的通用构建基块，并且已经探索了各种有前途的应用。在这篇综述中，我们讨论了由分支DNA组装而成的DNA功能材料的进展。我们首先简要介绍有关DNA分子的背景信息，并概述由分支DNA构成的DNA功能材料的发展历史。在第二部分中，将分支DNA作为构建基块的合成策略分为碱基配对组装和化学键合。在第三部分中，对基于支链DNA的功能材料的构建策略进行了全面总结，包括平铺介导的组装，DNA折纸，动态组装和混合组装。在第四部分中，演示了应用程序，包括诊断，蛋白质工程，药物和基因传递，治疗和细胞工程。最后，提供了对挑战和未来前景的见解。
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