The authors¹ present a nested case control study investigating the effects of smoking and hypertension on the prevalence of unruptured intracranial aneurysms (UIA) in female patients 30 to 60 yr of age. The patients had a brain magnetic resonance angiography (MRA) obtained between 2016 and 2018. In patients with a history of smoking, the prevalence of an UIA was 10-times higher (19% vs 1.9%) than for non-smokers. There was a significant association of smoking, hypertension, or a combination thereof with incidental UIAs. Smoking is often accompanied by hypertension, and both are known to be associated with UIA. While several previous studies have indicated a causal relationship between smoking or hypertension and intracranial aneurysm formation, an isolated analysis has rarely been performed. Therefore, the authors analyzed both their isolated and combined impact on the prevalence of UIAs and excluded patients with other known risk factors such as polycystic kidney disease or a family history of intracranial aneurysms.

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评论：与不吸烟者相比，接触过第一手烟草烟雾的女性患未破裂颅内动脉瘤的可能性更高：嵌套病例对照研究。

作者¹提出一项巢式病例对照研究，调查吸烟和高血压对 30 至 60 岁女性患者未破裂颅内动脉瘤 (UIA) 患病率的影响。这些患者在 2016 年至 2018 年期间进行了脑磁共振血管造影 (MRA)。在有吸烟史的患者中，UIA 的患病率是非吸烟者的 10 倍（19% 对 1.9%）。吸烟、高血压或其组合与偶发性 UIAs 之间存在显着关联。吸烟通常伴有高血压，两者都与 UIA 相关。虽然之前的几项研究表明吸烟或高血压与颅内动脉瘤形成之间存在因果关系，但很少进行单独的分析。所以，