Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood brain tumor and the majority of patients die within 2 yr after initial diagnosis. Factors that contribute to the dismal prognosis of these patients include the infiltrative nature and anatomic location in an eloquent area of the brain, which precludes total surgical resection, and the presence of the blood-brain barrier (BBB), which reduces the distribution of systemically administered agents. Convection-enhanced delivery (CED) is a direct infusion technique to deliver therapeutic agents into a target site in the brain and able to deliver a high concentration drug to the infusion site without systemic toxicities.

中文翻译：

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Zeste Homolog-2 (EZH2) 抑制剂增强剂的对流增强递送用于治疗弥漫性脑桥神经胶质瘤。

弥漫性脑桥脑胶质瘤 (DIPG) 是一种致命的儿童脑肿瘤，大多数患者在初次诊断后 2 年内死亡。导致这些患者预后不良的因素包括脑部功能区的浸润性和解剖位置，这排除了全手术切除，以及血脑屏障 (BBB) 的存在，这减少了全身性分布管理的代理。对流增强输送 (CED) 是一种直接输注技术，可将治疗剂输送到大脑中的目标部位，并能够将高浓度药物输送到输注部位，而不会产生全身毒性。