Gamma-hydroxybutyrate (GHB) is misused as an intoxicant, either alone or concurrently with other substances. Because GHB is illegal, the precursor chemicals 1,4-butanediol and gamma-butyrolactone are also misused for the same effect, either through pre-ingestion alteration or endogenous metabolism to GHB. We describe a case of a 50-year-old-man with a history of polysubstance misuse who experienced an overdose of GHB from gamma-butyrolactone ingestion. The patient also co-ingested a common industrial solvent, N-methyl-2-pyrrolidone (NMP). This co-ingested substance raised theoretical concern of metabolism to a GHB congener, underscoring that the emergence of new psychoactive substance use patterns requires ongoing vigilance and toxicologic confirmation.

中文翻译：

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γ-丁内酯过量可能会因共同摄入工业溶剂N-甲基-2-吡咯烷酮而变得复杂。

γ-羟基丁酸酯（GHB）单独或与其他物质同时被误用作麻醉剂。由于GHB是非法的，因此前体化学物质1,4-丁二醇和γ-丁内酯也因滥用前的改变或内源性代谢而被滥用以达到相同的效果。我们描述了一个有多物质滥用历史的50岁男子的案例，该人因摄入γ-丁内酯经历了过量的GHB。该患者还食用了一种常见的工业溶剂N-甲基-2-吡咯烷酮（NMP）。这种共同摄取的物质引起了GHB同源物在代谢方面的理论关注，强调新的精神活性物质使用方式的出现需要持续的警惕和毒理学确认。