In case of basic biological materials (blood, urine, vitreous humor) being unavailable, bone marrow can be used for toxicological tests. The aim of the study was to assess the concentration of various xenobiotics in the bone marrow, as well as in the blood and the vitreous humor. The analysis was performed in the biological material originating from the autopsy (n = 120), using the LC–MS method and with liquid/liquid extraction at pH = 9. As many as 46 different xenobiotics were detected in the biological material, strong correlations between the concentration of a given xenobiotic in blood and bone marrow, as well as in the vitreous humor and bone marrow, were noted for most of them, with the exception of diazepam and 7-aminoclonazepam. The obtained results indicate the possibility of using bone marrow to determine the concentration of numerous xenobiotics in the situation of basic biological materials being unavailable, as well as using the results obtained in the future to better understand the pharmacokinetic processes and the effect of postmortem redistribution on medication and drug concentrations in the body of a deceased person.

中文翻译：

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血液，玻璃体液和骨髓抽吸物的死后标本中药物的检测

如果没有基本的生物材料（血液，尿液，玻璃体液），可以使用骨髓进行毒理学测试。该研究的目的是评估骨髓以及血液和玻璃体液中各种异生素的浓度。对源自尸体解剖的生物材料进行分析（n = 120），使用LC-MS方法，并在pH = 9时进行液/液萃取。在生物材料中检测到多达46种不同的异种生物，血液和骨髓中给定异种生物的浓度之间存在很强的相关性，如下所示：除地西epa和7-氨基氯硝西am外，其余大多数均在玻璃体液和骨髓中被发现。获得的结果表明，在无法获得基本生物材料的情况下，可以使用骨髓来确定多种异生物素的浓度，并且可以使用将来获得的结果更好地了解药代动力学过程和死后重新分布对死者体内的药物和药物浓度。