Abstract

Synthetic micro/nanomotors (MNMs) are novel, self-propelled nano or microscale devices that are widely used in drug transport, cell stimulation and isolation, bio-imaging, diagnostic and monitoring, sensing, photocatalysis and environmental remediation. Various preparation methods and propulsion mechanisms make MNMs “tailormade” nanosystems for the intended purpose or use. As the one of the newest members of nano carriers, MNMs open a new perspective especially for rapid drug transport and gene delivery. Although there exists limited number of in-vivo studies for drug delivery purposes, existence of in-vitro supportive data strongly encourages researchers to move on in this field and benefit from the manoeuvre capability of these novel systems. In this article, we reviewed the preparation and propulsion mechanisms of nanomotors in various fields with special attention to drug delivery systems.

摘要

合成微/纳米马达 (MNM) 是一种新型的自驱动纳米或微米级装置，广泛用于药物运输、细胞刺激和分离、生物成像、诊断和监测、传感、光催化和环境修复。各种制备方法和推进机制使 MNM为预期目的或用途“量身定制”纳米系统。作为纳米载体的最新成员之一，MNMs 开辟了一个新的视角，尤其是在快速药物运输和基因传递方面。虽然存在的有限数量的被检体内用于药物递送目的的研究中，存在的体外支持性数据强烈鼓励研究人员在该领域继续前进，并从这些新型系统的机动能力中受益。在这篇文章中，我们回顾了纳米马达在各个领域的制备和推进机制，特别关注药物递送系统。