Physalis Calyx seu Fructus, a traditional Chinese medicine consisting of the calyxes and fruits of Physalis alkekengi var. franchetii, has been used as therapy for inflammation-related respiratory diseases such as excessive phlegm, cough, sore throat, and pharyngitis for a long history in China. The aim of the present study was to investigate the chemical constituents of Physalis Calyx seu Fructus and identify the bioactive constituents responsible for its traditional application as therapy for inflammation-related diseases. In the present study, one new phenylpropanoid (1: ), two new steroids (17: and 18: ), together with 55 known constituents have been purified from the EtOH extract of Physalis Calyx seu Fructus. Among them, seven and twelve known constituents were isolated for the first time from Physalis Calyx seu Fructus and the genus Physalis, respectively. Fourteen constituents, including steroids [physalins (5: - 9, 12: - 14: , and 15: ) and ergostane (21: )], a sesquiterpenoid (35: ), alkaloids (36: and 37: ), and a flavonoid (44: ), showed inhibitory effects against oxidative stress. Ten constituents, including steroids (5, 6, 8, 13: , and 15: ), sesquiterpenoids (34: and 35: ), alkaloids (37: and 41: ), and a flavonoid (43: ), were found be potential anti-inflammatory constituents of this medicinal plant. The inhibition of oxidative stress and inflammatory response may be related to the regulation of Nrf2 and nuclear factor-κB pathways. The ethnomedical use of Physalis Calyx seu Fructus as a treatment for respiratory diseases might be attributed to the combined inhibitory effects of steroids, alkaloids, sesquiterpenoids, and flavonoids against oxidative stress and inflammatory response.

中文翻译：

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酸浆的化学成分及其对氧化应激和炎症反应的抑制作用

Physalis Calyx seu Fructus 是一种中药，由 Physalis alkekengi var. 的花萼和果实组成。franchetii在我国用于治疗痰多、咳嗽、咽痛、咽炎等炎症相关的呼吸系统疾病已有悠久的历史。本研究的目的是研究 Physalis Calyx seu Fructus 的化学成分，并确定其传统应用作为炎症相关疾病疗法的生物活性成分。在本研究中，一种新的苯丙烷 (1: )、两种新的类固醇 (17: 和 18: ) 以及 55 种已知成分已从 Physalis Calyx seu Fructus 的 EtOH 提取物中纯化出来。他们之中，分别从 Physalis Calyx seu Fructus 和 Physalis 属中首次分离出 7 种和 12 种已知成分。十四种成分，包括类固醇 [physalins (5: - 9, 12: - 14: 和 15: ) 和麦角烷 (21: )]、倍半萜 (35: )、生物碱 (36: 和 37: ) 和黄酮类化合物(44: )，显示出对氧化应激的抑制作用。发现十种成分，包括类固醇（5、6、8、13: 和 15: ）、倍半萜类化合物（34: 和 35: ）、生物碱（37: 和 41: ）和黄酮类（43: ）这种药用植物的抗炎成分。氧化应激和炎症反应的抑制可能与Nrf2和核因子-κB通路的调节有关。