Porous Lanthanum‐Doped Manganese Oxide Nanoparticles for Enhanced Sonodynamic Cancer Therapy,Particle & Particle Systems Characterization

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Porous Lanthanum‐Doped Manganese Oxide Nanoparticles for Enhanced Sonodynamic Cancer Therapy
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-07-16 , DOI: 10.1002/ppsc.202000143
Jinhao Zhou ₁ , Liyin Shi ₁ , Qiyu Liu ₁ , Haozhe Zhang ₁ , Xiaoqing Liu ₁ , Feng Han ₁ , Zhixing Guo ₁ , Xihong Lu ₁ , Jianwei Wang ₁

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Metal oxides hold great promise as robust sonosensitizers for sonodynamic therapy (SDT). However, they usually suffer from limited production yield of reactive oxygen species (ROS) due to the fast recombination of ultrasound‐triggered electrons and holes. Herein, porous lanthanum (La)‐doped MnO₂ (LMO) nanoparticles are firstly developed as promising sonosensitizers in SDT. The strategic introduction of La dopants greatly promotes the separation efficiency of ultrasound‐triggered electrons and holes of MnO₂, endowing them with significantly improved ROS yield. Consequently, the LMO with polyethylene glycol decoration exhibits good SDT activity toward breast cancer cells. This work highlights the doping strategy for the development of enhanced ROS production of metal oxide sonosensitizers for SDT.

中文翻译：

多孔镧掺杂氧化锰纳米粒子增强声动力学癌症治疗。

金属氧化物作为用于声动力疗法（SDT）的强大的声敏剂具有广阔的前景。但是，由于超声触发的电子和空穴的快速结合，它们通常受到活性氧（ROS）产量限制的困扰。在此，多孔镧（La）掺杂的MnO ₂（LMO）纳米颗粒首先被开发为SDT中有希望的声敏剂。La掺杂剂的战略性引入极大地提高了超声触发的电子与MnO ₂空穴的分离效率，赋予它们显着提高的ROS产量。因此，带有聚乙二醇装饰的LMO对乳腺癌细胞表现出良好的SDT活性。这项工作突出了用于提高SDT的金属氧化物声敏剂的ROS产量开发的掺杂策略。

更新日期：2020-07-16

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