Synthesis of peptide conjugates with vitamins for induction of antigen-specific immunotolerance.,Journal of Peptide Science

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Synthesis of peptide conjugates with vitamins for induction of antigen-specific immunotolerance.
Journal of Peptide Science ( IF 1.8 ) Pub Date : 2020-07-15 , DOI: 10.1002/psc.3275
Kazuki Yuzuriha ₁ , Ayaka Yoshida ₁ , Shunyi Li ₁ , Akihiro Kishimura _{1,

2,

3,

4} , Takeshi Mori _{1,

2,

3} , Yoshiki Katayama _{1,

2,

3,

4,

5}

Affiliation

In this report, we designed conjugates of an antigen peptide with the immunosuppressive vitamins all‐trans retinoic acid (ATRA) and vitamin D3 for efficient induction of antigen‐specific immunotolerance. We established a synthetic scheme for the preparation of the peptide‐vitamin conjugates, which the chemically unstable vitamins tolerated. Among the obtained conjugates, the ATRA conjugate successfully suppressed inflammatory effects in macrophages and dendritic cells and induced antigen presentation in dendritic cells. This synthetic method of conjugate is conceivably applicable to other antigen peptides for induction of antigen‐specific immunotolerance.

中文翻译：

合成具有维生素的肽共轭物，用于诱导抗原特异性免疫耐受。

在本报告中，我们设计了抗原肽与免疫抑制性维生素全反式维甲酸（ATRA）和维生素D3的结合物，以有效诱导抗原特异性免疫耐受。我们建立了肽-维生素结合物的合成方案，该结合物可耐受化学上不稳定的维生素。在获得的结合物中，ATRA结合物成功地抑制了巨噬细胞和树突细胞的炎症作用，并诱导了树突细胞中的抗原呈递。这种结合物的合成方法可以想象适用于其他抗原肽，以诱导抗原特异性免疫耐受。

更新日期：2020-07-15

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