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Chemical constituents from endophytic fungus Annulohypoxylon cf. stygium in leaves of Anoectochilus roxburghii (Wall.) Lindl
Chemistry & Biodiversity ( IF 2.3 ) Pub Date : 2020-08-31 , DOI: 10.1002/cbdv.202000424
Shuo Gao 1 , Wen-Jing Tian 1 , Zu-Jian Liao 1 , Guang-Hui Wang 1 , De-Quan Zeng 1 , Xiang-Zhong Liu 1 , Xiao-Yao Wang 1 , Hu Zhou 1 , Hai-Feng Chen 1 , Ting Lin 1
Affiliation  

The chemical investigation on endophytic fungus Annulohypoxylon cf. stygium in leaves of Anoectochilus roxburghii (Wall.) Lindl. has been performed. Sixteen compounds were isolated and their structures were identified as (−)‐notoamide A, (−)‐notoamide B, (+)‐versicolamide B, notoamide C, notoamide D, stephacidin A, sterigmatocystin, dihydrosterigmatocystin, secosterigmatocystin, versiconol, averufanin, kipukasin D, kipukasin E, diorcinal, palmarumycin CP2 and (−)‐(3R)‐mellein methyl ether, respectively, by spectroscopic analysis and comparison with literature data. All the compounds were isolated from Annulohypoxylon genus for the first time. Sterigmatocystin and palmarumycin CP2 showed selective cytotoxic activities against HepG2, HeLa, MCF‐7 and HT‐29.

中文翻译:

来自内生真菌 Annulohypoxylon 的化学成分 参见。Anoectochilus roxburghii (Wall.) Lindl 叶子中的 stygium

内生真菌 Annulohypoxylon 的化学研究 cf. Anoectochilus roxburghii (Wall.) Lindl 叶子中的 stygium。已执行。分离出 16 种化合物,它们的结构被鉴定为 (-)-notoamide A、(-)-notoamide B、(+)-versicolamide B、notoamide C、notoamide D、stephacidin A、sterigmatocystin、dihydrosterigmatocystin、secosterigmatocystin、versiconol、averufanin、 kipukasin D, kipukasin E, diorcinal, palmarumycin CP2 和 (-)-(3R)-mellein 甲基醚,分别通过光谱分析和与文献数据的比较。所有化合物均为首次从 Annulohypoxylon 属中分离得到。Sterigmatocystin 和 palmarumycin CP2 对 HepG2、HeLa、MCF-7 和 HT-29 显示出选择性的细胞毒活性。
更新日期:2020-08-31
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