Abstract Recently, graphene has been applied to modify biomaterials due to excellent physicochemical property and biocompatibility. However, some problems still exist especially the weak binding force between graphene and other biomaterials. Herein, a promising platform with photothermal property was constructed by fabricating the adhesive graphene in situ on the surface of β-tricalcium phosphate (β-Ca3(PO4)2, β-TCP) bioceramics using chemical vapor deposition (CVD). The result of ultrasonic cleaning treatment of graphene modified β-TCP (G-TCP) demonstrated that the prepared graphene coating could firmly modified on β-TCP due to the occurrence of carbothermal reduction on the ceramic surface to promote the nucleation and growth of graphene. G-TCP composites exhibited excellent photothermal effects when irradiated with 808 nm near-infrared laser (NIR). The photothermal effect of G-TCP composites could induce more than 90% of osteosarcoma cell (MNNG) death in vitro. These results confirmed that the graphene could be successfully fabricated in situ on the surface of β-TCP by CVD method, and exhibited high firmness and excellent photothermal performance, revealing a promising application in the photothermal therapy of bone tumors.

中文翻译：

---

在具有光热特性的生物陶瓷上生长的粘性石墨烯

摘要 近年来，石墨烯因其优异的理化性质和生物相容性而被应用于生物材料的改性。然而，仍然存在一些问题，特别是石墨烯与其他生物材料之间的结合力较弱。在此，通过使用化学气相沉积（CVD）在 β-磷酸三钙（β-Ca3（PO4）2，β-TCP）生物陶瓷表面原位制备粘性石墨烯，构建了一个具有光热性能的有前景的平台。对石墨烯改性β-TCP（G-TCP）进行超声波清洗处理的结果表明，由于陶瓷表面发生碳热还原，从而促进石墨烯的成核和生长，所制备的石墨烯涂层可以牢固地改性在β-TCP上。G-TCP 复合材料在 808 nm 近红外激光 (NIR) 照射下表现出优异的光热效应。G-TCP 复合材料的光热效应可在体外诱导超过 90% 的骨肉瘤细胞 (MNNG) 死亡。这些结果证实了通过CVD方法可以成功地在β-TCP表面原位制备石墨烯，并表现出高硬度和优异的光热性能，在骨肿瘤的光热治疗中具有广阔的应用前景。