PURPOSE We investigated whether the proportion of intracerebral haemorrhage (ICH) due to cerebral amyloid angiopathy (CAA) differs between patients admitted to hospitals in the East and the West. METHODS This international cross-sectional study included consecutive spontaneous ICH patients admitted to one stroke centre in the United Kingdom (Western centre origin) and one in Japan (Eastern centre origin) during the same period. We classified spontaneous ICH into "CAA-related" or "other" using the Edinburgh CT-based diagnostic criteria. We used multivariable logistic regression analyses to assess the relationship between CAA-related ICH and geographical location or ethnicity (White vs. East Asian or other ethnicities). Sensitivity analyses were performed using the modified Boston MRI-based diagnostic criteria for CAA-related ICH. RESULTS Of 433 patients (median age, 72 years; Western centre origin, 55%), 15% were classified as CAA-related ICH. In the multivariable logistic regression model, Eastern centre and ethnicity had a lower proportion of CAA-related ICH (odds ratio [OR] vs Western centre origin 0.55, 95%CI 0.31-0.98; OR [vs. White] 0.47, 95%CI 0.25-0.87); these findings remained robust in sensitivity analyses. The estimated incidence of "other" (non-CAA) ICH (attributed to hypertensive arteriopathy) was 2.5-fold higher in East Asian populations. CONCLUSIONS The proportion CAA-related ICH is lower in an Eastern compared to a Western hospital ICH population; this might be explained by a higher incidence of ICH related to hypertensive arteriopathy in East Asian populations, suggesting that optimal ICH prevention strategies might differ between the East and West.

中文翻译：

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东西方脑淀粉样血管病致脑出血的比例：日本和英国单一医院中心的比较

目的 我们调查了东西方住院患者因脑淀粉样血管病 (CAA) 引起的脑内出血 (ICH) 的比例是否不同。方法 这项国际横断面研究包括同一时期在英国的一个卒中中心（起源于西方中心）和日本（起源于东部中心）的一个卒中中心连续收治的自发性 ICH 患者。我们使用基于爱丁堡 CT 的诊断标准将自发性 ICH 分为“CAA 相关”或“其他”。我们使用多变量逻辑回归分析来评估 CAA 相关 ICH 与地理位置或种族（白人与东亚或其他种族）之间的关系。使用改良的基于波士顿 MRI 的 CAA 相关 ICH 诊断标准进行敏感性分析。结果 在 433 名患者（中位年龄，72 岁；西方中心起源，55%）中，15% 被归类为 CAA 相关 ICH。在多变量逻辑回归模型中，东部中心和种族的 CAA 相关 ICH 比例较低（比值比 [OR] 与西部中心起源 0.55，95%CI 0.31-0.98；OR [与白人] 0.47，95%CI 0.25-0.87)；这些发现在敏感性分析中仍然很可靠。“其他”（非 CAA）ICH（归因于高血压动脉病）的估计发病率在东亚人群中高 2.5 倍。结论 与西方医院 ICH 人群相比，东部地区 CAA 相关 ICH 的比例较低；这可能是由于东亚人群中与高血压动脉病相关的 ICH 发生率较高，