BACKGROUND With constant changes in neonatal care practices, recent information is valuable for healthcare providers and for parental counselling. The aim of the study was to describe the neurodevelopmental outcome in a cohort of very preterm (VPT)/very-low-birthweight (VLBW) infants at 2 years corrected age (CA). MATERIAL AND METHODS This is a population-based cohort study of all infants born with a GA <31 weeks and/or BW < 1500 g between 2014 and 2016 admitted to the Flemish (Belgium) neonatal intensive care units. Infants had routine clinical follow-up around 2 years CA. The diagnosis of cerebral palsy (CP), visual and hearing impairments were recorded. Motor, cognitive and language outcomes were assessed using the Bayley-III. Neurodevelopmental impairment (NDI) was classified as mild (<1 standard deviation [SD]) or moderate-severe (<2SD) based on the defined categories of motor, cognitive, hearing, and vision impairments. RESULTS Of the 1941 admissions, 92% survived to discharge and follow-up data were available for 1089 infants (61.1%). Overall, 19.3%, 18.9% and 41.8% of infants had a motor, cognitive and language delay, respectively. CP was diagnosed in 4.3% of the infants. Mild and moderate-to-severe NDI was observed in 25.2% and 10.9% of the infants, respectively. The number of infants with a normal outcome increased from nearly 40% in the category of GA<26 weeks to 70% for infants in the category of 30─31 weeks GA. CONCLUSION At 2 years CA, 64% were free from NDI and 90% were free from moderate-to-severe NDI. However, a lower GA and BW are associated with higher rates of adverse neurodevelopmental outcomes at 2 years CA.

中文翻译：

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具有明确围产期治疗政策的基于人群的临床队列中极早产儿和极低出生体重儿的神经发育结果

背景随着新生儿护理实践的不断变化，最近的信息对于医疗保健提供者和父母咨询是有价值的。该研究的目的是描述一组 2 岁矫正年龄 (CA) 的极早产 (VPT)/极低出生体重 (VLBW) 婴儿的神经发育结果。材料和方法 这是一项基于人群的队列研究，研究对象是 2014 年至 2016 年间入住佛兰芒（比利时）新生儿重症监护病房的所有出生体重 <31 周和/或 BW < 1500 g 的婴儿。婴儿进行了大约 2 年 CA 的常规临床随访。记录脑瘫（CP）、视力和听力障碍的诊断。使用 Bayley-III 评估运动、认知和语言结果。神经发育障碍 (NDI) 被归类为轻度 (< 1 标准差 [SD]) 或中重度 (<2SD) 基于定义的运动、认知、听力和视力障碍类别。结果 在 1941 名入院患者中，92% 存活出院，并且可获得 1089 名婴儿 (61.1%) 的随访数据。总体而言，分别有 19.3%、18.9% 和 41.8% 的婴儿出现运动、认知和语言延迟。4.3% 的婴儿被诊断为 CP。分别在 25.2% 和 10.9% 的婴儿中观察到轻度和中度至重度 NDI。结果正常的婴儿数量从 GA<26 周类别的近 40% 增加到 30─31 周 GA 类别的婴儿的 70%。结论 在 2 年 CA 时，64% 没有 NDI，90% 没有中度至重度 NDI。然而，