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Pathogen Interference: Targeting Virulence Factors to Tackle Intracellular Microbes.
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2020-07-16 , DOI: 10.1016/j.chembiol.2020.06.017 Michael H Lee 1 , Sean-Paul Nuccio 1 , Manuela Raffatellu 2
中文翻译:
病原体干扰:靶向毒力因子以解决细胞内微生物。
更新日期:2020-07-16
Cell Chemical Biology ( IF 6.6 ) Pub Date : 2020-07-16 , DOI: 10.1016/j.chembiol.2020.06.017 Michael H Lee 1 , Sean-Paul Nuccio 1 , Manuela Raffatellu 2
Affiliation
Infections with Salmonella enterica pose a challenge for antibiotic treatment. In this issue of Cell Chemical Biology, Tsai et al. use a chemical genomics approach to identify dephostatin as an inhibitor of intracellular Salmonella virulence in vitro and in vivo by targeting the two-component systems SsrA-SsrB and PmrB-PmrA.
中文翻译:
病原体干扰:靶向毒力因子以解决细胞内微生物。
肠道沙门氏菌感染对抗生素治疗提出了挑战。在本期《细胞化学生物学》中,Tsai 等人。使用化学基因组学方法,通过靶向双组分系统 SsrA-SsrB 和 PmrB-PmrA,在体外和体内鉴定去磷他汀作为细胞内沙门氏菌毒力的抑制剂。