A method has been developed for preparation of surface molecularly imprinted polymer functionalized silica nanoparticles (SiO2@MPS@MIP). Firstly, the silica nanoparticles are prepared by a one-pot sol-gel method using tetraethylorthosilicate and 3-methacryloxypropyltrimethoxysilane as functional monomers. Next, the template molecule (L-Trp) is self-assembled with the functional monomer (acrylamide). Finally, SiO2@MPS@MIP are prepared using N,N′-methylenebisacrylamide as the cross-linker. The prepared SiO2@MPS@MIP have an average diameter of about 6.3 ± 1.2 nm. They exhibit good selectivity toward L-Trp with an imprinting factor of 6.3. The adsorption isotherm data was well described by the Langmuir model. The maximum adsorption capacities of SiO2@MPS@MIP for L-Trp and D-Trp were calculated to be 11.1 ± 0.9 and 2.66 ± 0.16 mg g−1, respectively. An enantiomer excess value of 100% was achieved after adsorption of racemic Trp by the material. The work suggests that SiO2@MPS@MIP are a promising material for enantioseparation of Trp racemate in aqueous media. Graphical abstract Graphical abstract

中文翻译：

---

分子印迹聚合物官能化二氧化硅纳米粒子，用于水溶液中外消旋色氨酸的对映分离

开发了一种制备表面分子印迹聚合物功能化二氧化硅纳米粒子（SiO2@MPS@MIP）的方法。首先，使用原硅酸四乙酯和3-甲基丙烯酰氧基丙基三甲氧基硅烷作为功能单体，通过一锅溶胶-凝胶法制备二氧化硅纳米粒子。接下来，模板分子 (L-Trp) 与功能单体 (丙烯酰胺) 自组装。最后，使用N,N'-亚甲基双丙烯酰胺作为交联剂制备SiO2@MPS@MIP。制备的 SiO2@MPS@MIP 的平均直径约为 6.3 ± 1.2 nm。它们对 L-Trp 表现出良好的选择性，印记因子为 6.3。Langmuir 模型很好地描述了吸附等温线数据。经计算，SiO2@MPS@MIP 对 L-Trp 和 D-Trp 的最大吸附容量分别为 11.1 ± 0.9 和 2.66 ± 0.16 mg g-1。材料吸附外消旋色氨酸后，对映体过量值达到 100%。研究表明，SiO2@MPS@MIP 是一种很有前途的材料，可用于在水性介质中对映体分离色氨酸外消旋体。图形摘要图形摘要