Foveal structure that is specified by the thickness, depth and the overall shape of the fovea is a promising tool to qualify and quantify retinal pathology in Parkinson’s disease. To determine the model variable that is best suited for discriminating Parkinson’s disease eyes from those of healthy controls and to assess correlations between impaired contrast sensitivity and foveal shape we characterized the fovea in 48 Parkinson’s disease patients and 45 control subjects by optical coherence tomography (OCT). The model quantifies structural changes in the fovea of Parkinson’s disease patients that are correlated with a decline in contrast sensitivity. Retinal foveal remodeling may serve as a parameter for vision deficits in Parkinson’s disease. Whether foveal remodeling reflects dopaminergic driven pathology or rather both dopaminergic and non-dopaminergic pathology has to be investigated in longitudinal studies.

由中央凹的厚度、深度和整体形状指定的中央凹结构是鉴定和量化帕金森病视网膜病理的有前途的工具。为了确定最适合区分帕金森病眼睛和健康对照眼睛的模型变量，并评估对比敏感度受损和中央凹形状之间的相关性，我们通过光学相干断层扫描 (OCT) 对 48 名帕金森病患者和 45 名对照受试者的中央凹进行了表征. 该模型量化了与对比敏感度下降相关的帕金森病患者中央凹的结构变化。视网膜中央凹重塑可作为帕金森病视力缺陷的一个参数。