The two biological evidences to endorse the antiviral activity of RNA interference (RNAi) are biogenesis of viral-siRNA (v-siRNA) by the host and encoding of RNAi-suppressor protein by viral genome. It has been recently established that mammals and mammalian cell lines mount antiviral RNAi to defend themselves against the invading viruses. The large part of viral pathogenicity is also due to the RNAi suppressor proteins. In this context it is only natural to ask what kinds of RNAi suppressors are encoded by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the central character of the present pandemic. The following mini review addresses this question.

中文翻译：

---

RNAi抑制剂：SARS-CoV的隐藏武器

支持 RNA 干扰 (RNAi) 抗病毒活性的两个生物学证据是宿主对病毒-siRNA (v-siRNA) 的生物发生和病毒基因组对 RNAi 抑制蛋白的编码。最近已经确定，哺乳动物和哺乳动物细胞系安装抗病毒 RNAi 以保护自己免受入侵病毒的侵害。病毒致病性的很大一部分也是由于 RNAi 抑制蛋白。在这种情况下，很自然地会问，严重急性呼吸系统综合症冠状病毒 2 (SARS-CoV-2) 编码了哪些类型的 RNAi 抑制因子，这是当前大流行的核心特征。下面的小评论解决了这个问题。