Nanomaterial structures are highly contributive in tissue engineering vascular scaffolds (TEVS) due to their ability to mimic the nanoscale dimension of the natural extracellular matrix (ECM) and the existing mechanical match between the native blood vessel and the scaffold as a vascular graft. The aim of this study was to develop and mechanically improve the nanofibrous triad-hybrid scaffolds with different composite ratios of polyethylene terephthalate (PET), polyurethane (PU), and polycaprolactone (PCL). The morphological, biological, mechanical, and biomechanical properties of the neat and hybrid structures were examined using scanning electron microscopy (SEM), differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FTIR), tensile strength, compliance, burst pressure, MTT assay, and by implanting the specimens under rat skin to explore the immune system in vivo . The results showed that the fiber diameter and porosity changes in the triad-hyb...

中文翻译：

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一种新型顺应性小直径 PET/PU/PCL 三联体混合血管移植物的制造和表征。

纳米材料结构在组织工程血管支架 (TEVS) 中非常重要，因为它们能够模拟天然细胞外基质 (ECM) 的纳米级尺寸以及天然血管和支架作为血管移植物之间的现有机械匹配。本研究的目的是开发和机械改进具有不同复合比例的聚对苯二甲酸乙二醇酯 (PET)、聚氨酯 (PU) 和聚己内酯 (PCL) 的纳米纤维三联体混合支架。使用扫描电子显微镜 (SEM)、差示扫描量热法 (DSC)、傅里叶变换红外光谱 (FTIR)、拉伸强度、顺应性、爆破压力、MTT 检查了纯结构和混合结构的形态、生物学、机械和生物力学性能化验，并通过将标本植入大鼠皮下来探索体内免疫系统。结果表明，三联体中纤维直径和孔隙率发生变化。