Natural Product Communications ( IF 1.5 ) Pub Date : 2020-07-14 , DOI: 10.1177/1934578x20939408 Ji-Yul Kim 1 , Eunjung Son 1 , Dong-Seon Kim 1
A new veratramine-type alkaloid (1), along with 4 known compounds (2-5), was isolated from the roots of Veratrum maackii var. japonicum (Baker) T. Shimizu. Their structures were elucidated on the basis of NMR and mass spectroscopic data. All compounds were evaluated for their antioxidant activities using 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS+) and 2,2-diphenyl-1-picrylhydrazyl (DPPH·) radical scavenging assays. Compounds 1 and 3-5 showed ABTS+ radical scavenging activity with IC50 values ranging from 15.0 to 85.7 μM.
中文翻译:
一种来自藜芦的新藜芦碱型生物碱。日本ap和离体化合物的抗氧化活性
从藜芦(Veratrum maackii var)的根中分离出一种新的藜芦类生物碱(1)和4种已知化合物(2-5)。日本(贝克)T.清水。根据NMR和质谱数据阐明了它们的结构。使用2,2'-叠氮基双(3-乙基苯并噻唑啉-6-磺酸)(ABTS +)和2,2-二苯基-1-吡啶并肼基(DPPH ·)自由基清除试验评估所有化合物的抗氧化活性。化合物1和3 - 5表明ABTS +与IC自由基清除活性50值范围从15.0至85.7微米。