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Dark Classics in Chemical Neuroscience: An Evidence-Based Systematic Review of Belladonna.
ACS Chemical Neuroscience ( IF 4.1 ) Pub Date : 2020-07-14 , DOI: 10.1021/acschemneuro.0c00413
Vimal K Maurya 1 , Swatantra Kumar 1 , Russell Kabir 2 , Gaurav Shrivastava 3 , Karuna Shanker 4 , Debadatta Nayak 5 , Anil Khurana 5 , Raj K Manchanda 5 , Srinivasulu Gadugu 6 , Sujita K Kar 7 , Anoop K Verma 8 , Shailendra K Saxena 1
Affiliation  

Belladonna has diverse pharmacotherapeutic properties with a shadowy history of beauty, life, and death. Alkaloids present in belladonna have anti-inflammatory, anticholinergic, antispasmodic, mydriatic, analgesic, anticonvulsant, and antimicrobial activities, which makes it widely applicable for the treatment of various diseases. However, because of its associated toxicity, the medicinal use of belladonna is debatable. Therefore, an evidence-based systematic review was planned to elucidate the pharmacotherapeutic potential of belladonna. A comprehensive literature search was performed in PubMed, MEDLINE, the Cochrane database, Embase, and ClinicalTrials.gov using the keywords “belladonna”, “belladonna and clinical trials”, and “safety and efficacy of belladonna”. Articles published from 1965 to 2020 showing the efficacy of belladonna in diverse clinical conditions are included. The quality of evidence was generated using the GRADE approach, and 20 studies involving 2302 patients were included for the systematic review. Our analyses suggest that belladonna treatment appears to be safe and effective in various disease conditions, including acute encephalitis syndrome, urethral stent pain, myocardial ischemia injury, airway obstructions during sleep in infants, climacteric complaints, irritable bowel syndrome, and throbbing headache. However, better understanding of the dosage and the toxicity of tropane alkaloids of belladonna could make it an efficient remedy for treating diverse medical conditions.

中文翻译:

化学神经科学中的黑暗经典:颠茄的循证系统评价。

颠茄具有多种药物治疗特性,具有美丽、生与死的阴暗历史。颠茄所含的生物碱具有抗炎、抗胆碱能、解痉、散瞳、镇痛、抗惊厥和抗菌等作用,可广泛用于治疗多种疾病。然而,由于其相关的毒性,颠茄的药用价值值得商榷。因此,计划进行循证系统评价以阐明颠茄的药物治疗潜力。在 PubMed、MEDLINE、Cochrane 数据库、Embase 和 ClinicalTrials.gov 中使用关键字“颠茄”、“颠茄和临床试验”以及“颠茄的安全性和有效性”进行了全面的文献搜索。1965 年至 2020 年发表的文章显示了颠茄在不同临床条件下的疗效。证据质量是使用 GRADE 方法生成的,涉及 2302 名患者的 20 项研究被纳入系统审查。我们的分析表明,颠茄治疗似乎对多种疾病都是安全有效的,包括急性脑炎综合征、尿道支架疼痛、心肌缺血损伤、婴儿睡眠期间气道阻塞、更年期主诉、肠易激综合征和搏动性头痛。然而,更好地了解颠茄托烷类生物碱的剂量和毒性可以使其成为治疗多种疾病的有效药物。系统评价纳入了涉及 2302 名患者的 20 项研究。我们的分析表明,颠茄治疗似乎对多种疾病都是安全有效的,包括急性脑炎综合征、尿道支架疼痛、心肌缺血损伤、婴儿睡眠期间气道阻塞、更年期主诉、肠易激综合征和搏动性头痛。然而,更好地了解颠茄托烷类生物碱的剂量和毒性可以使其成为治疗多种疾病的有效药物。系统评价纳入了涉及 2302 名患者的 20 项研究。我们的分析表明,颠茄治疗似乎对多种疾病都是安全有效的,包括急性脑炎综合征、尿道支架疼痛、心肌缺血损伤、婴儿睡眠期间气道阻塞、更年期主诉、肠易激综合征和搏动性头痛。然而,更好地了解颠茄托烷类生物碱的剂量和毒性可以使其成为治疗多种疾病的有效药物。婴儿睡眠期间气道阻塞、更年期不适、肠易激综合征和搏动性头痛。然而,更好地了解颠茄托烷类生物碱的剂量和毒性可以使其成为治疗多种疾病的有效药物。婴儿睡眠期间气道阻塞、更年期不适、肠易激综合征和搏动性头痛。然而,更好地了解颠茄托烷类生物碱的剂量和毒性可以使其成为治疗多种疾病的有效药物。
更新日期:2020-07-14
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