当前位置: X-MOL 学术Polycycl. Aromat. Compd. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
One-Pot Synthesis of Quinolinyl Amino Nitriles and Their Antidiabetic, Anti-inflammatory, Antioxidant, and Molecular Docking Studies
Polycyclic Aromatic Compounds ( IF 2.4 ) Pub Date : 2020-07-15 , DOI: 10.1080/10406638.2020.1791917
Ramesh Dalavai 1 , Kannayiram Gomathi 2 , K. Naresh 3 , Fazlur-Rahman Nawaz Khan 1
Affiliation  

Abstract

One-pot synthesis of quinolinyl amine nitriles, 8, was accounted from quinoline-3-carbaldehyde, 7, and amines (benzylic, aromatic, aliphatic, or hetero-aromatic) using Zn(CN)2/trifluoroethanol (TFE) system, an eco-friendly, and ambient protocol. Antidiabetic, anti-inflammatory, antioxidant, and molecular docking studies of 8a–l revealed moderate-to-good activity.



中文翻译:

喹啉基氨基腈的一锅法合成及其抗糖尿病、抗炎、抗氧化和分子对接研究

摘要

使用 Zn(CN) 2 /三氟乙醇 (TFE) 系统,从 quinoline-3-carbaldehyde, 7和胺(苄基、芳族、脂肪族或杂芳族)一锅法合成喹啉基胺腈8,环保和环境协议。8a-l的抗糖尿病、抗炎、抗氧化和分子对接研究显示有中等至良好的活性。

更新日期:2020-07-15
down
wechat
bug