Abstract

One-pot synthesis of quinolinyl amine nitriles, 8, was accounted from quinoline-3-carbaldehyde, 7, and amines (benzylic, aromatic, aliphatic, or hetero-aromatic) using Zn(CN)₂/trifluoroethanol (TFE) system, an eco-friendly, and ambient protocol. Antidiabetic, anti-inflammatory, antioxidant, and molecular docking studies of 8a–l revealed moderate-to-good activity.

中文翻译：

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喹啉基氨基腈的一锅法合成及其抗糖尿病、抗炎、抗氧化和分子对接研究

摘要

使用 Zn(CN) ₂ /三氟乙醇 (TFE) 系统，从 quinoline-3-carbaldehyde, 7和胺（苄基、芳族、脂肪族或杂芳族）一锅法合成喹啉基胺腈8，环保和环境协议。8a-l的抗糖尿病、抗炎、抗氧化和分子对接研究显示有中等至良好的活性。