Abstract

In the course of our efforts to search new secondary metabolites from marine-derived fungi, one new hexylitaconic acid derivative, 3-(5-methoxycarbonylpentyl)-4-methylfuran-2,5-dione (1), and two dimeric analogues asperwelwinates A and B (2 and 3), together with ten known compounds, asperitaconic acid C (4), kotanin (5) and orlandin (6), desertorin B (7), fonsecinone A (8), aurasperone A (9), asperpyrones B and C (10 and 11), aspernigrin B (12), and pyrophen (13), were isolated from a strain of Aspergillus welwitschiae CUGBMF180262. The structures of compounds 1–3 were determined by detailed analysis of HRMS, and 1D/2D NMR experiments, while the absolute configurations of 2 and 3 were determined by comparison of experimental and calculated electronic circular dichroism spectra. 2 and 3 were first reported dimeric hexylitaconic acid derivatives. Compounds 8, 9 and 11 showed moderate antibacterial activities against Helicobacter pylori with minimum inhibitory concentration (MIC) values of 16 μg/mL.

摘要

在我们努力从海洋衍生真菌中寻找新的次级代谢物的过程中，一种新的己基衣康酸衍生物 3-(5-methoxycarbonylpentyl)-4-methylfuran-2,5-dione ( 1 ) 和两种二聚体类似物 asperwelwinates A和 B ( 2和3 )，连同十种已知化合物，天冬康酸 C ( 4 )、kotanin ( 5 ) 和 orlandin ( 6 )、desertorin B ( 7 )、fonsecinone A ( 8 )、aurasperone A ( 9 )、asperpyrones B 和 C ( 10和11 )、aspernigrin B ( 12 ) 和 pyrophen ( 13 ) 是从一株万岁曲霉CUGBMF180262。化合物1-3的结构通过 HRMS 的详细分析和 1D/2D NMR 实验确定，而2和3的绝对构型通过比较实验和计算的电子圆二色光谱确定。2和3是首次报道的二聚己基衣康酸衍生物。化合物8，9个11显示出中等抗抗菌活性幽门螺杆菌用16微克/毫升的最小抑制浓度（MIC）值。