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Extracellular Vesicles in Fungi: Past, Present, and Future Perspectives.
Frontiers in Cellular and Infection Microbiology ( IF 5.7 ) Pub Date : 2020-06-05 , DOI: 10.3389/fcimb.2020.00346
Juliana Rizzo 1 , Marcio L Rodrigues 2, 3 , Guilhem Janbon 1
Affiliation  

Extracellular vesicles (EVs) have garnered much interest in the cell biology and biomedical research fields. Many studies have reported the existence of EVs in all types of living cells, including in fifteen different fungal genera. EVs play diverse biological roles, from the regulation of physiological events and response to specific environmental conditions to the mediation of highly complex interkingdom communications. This review will provide a historical perspective on EVs produced by fungi and an overview of the recent discoveries in the field. We will also review the current knowledge about EV biogenesis and cargo, their role in cell-to-cell interactions, and methods of EV analysis. Finally, we will discuss the perspectives of EVs as vehicles for the delivery of biologically active molecules.



中文翻译:

真菌中的细胞外囊泡:过去,现在和未来的观点。

细胞外囊泡(EVs)在细胞生物学和生物医学研究领域引起了极大的兴趣。许多研究报告了所有类型的活细胞,包括十五个不同的真菌属中都存在电动汽车。电动汽车扮演着各种各样的生物学角色,从生理事件的调节和对特定环境条件的响应到高度复杂的相互交流的中介。这篇综述将提供关于真菌生产的电动汽车的历史观点,并概述该领域的最新发现。我们还将回顾有关电动汽车生物发生和运输的当前知识,它们在细胞间相互作用中的作用以及电动汽车分析方法。最后,我们将讨论电动汽车作为生物活性分子输送媒介的观点。

更新日期:2020-07-15
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