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Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential
Planta Medica ( IF 2.1 ) Pub Date : 2020-07-14 , DOI: 10.1055/a-1178-5158
Deise Cristina Drummond Xavier Paes Lopes 1, 2 , Temistocles Barroso de Oliveira 3 , Alessandra Lifsitch Viçosa 2 , Simone Sacramento Valverde 3 , Eduardo Ricci Júnior 1
Affiliation  

Compositae is the largest family of flowering plants, with more than 1600 genera and 22 000 species. It has many economic uses in foods, cosmetics, and pharmaceutics. The literature reports its numerous medicinal benefits and recognized anti-inflammatory activity. Thus, this study evaluated the technological trends of anti-inflammatory activity of Compositae, based on the survey of scientific databases, articles, and patents, as well as the website of the Brazilian National Health Regulatory Agency (ANVISA), which is responsible for registering and controlling of healthcare and cosmetic products in the Brazil. The survey was conducted between 2008 and 2018, in the databases Science Direct, Lilacs, PubMed, and Web of Science (main collection), as well as the SciELO Citation Index. The patent survey was carried out on the basis of the Derwent Innovations Index, an important source for worldwide patent consultation, which covers 20 y of registered patents. Despite the numerous studies involving species of the Compositae family in different models of anti-inflammatory activity, there are few records of patents or products on the market from these species for that purpose. Some species have a traditional use and are present even in the Phytotherapic Summary of the Brazilian Pharmacopeia. This review confirms the therapeutic potential of Compositae for the development of anti-inflammatory drugs and reinforces the need to develop competencies and reduce technological bottlenecks to promote research and innovation in biodiversity products.

中文翻译:

菊科的抗炎活性及其治疗潜力

菊科是最大的开花植物科,有 1600 多个属和 22000 个种。它在食品、化妆品和制药方面有许多经济用途。文献报道了它的众多药用价值和公认的抗炎活性。因此,本研究基于对科学数据库、文章和专利的调查,以及负责注册的巴西国家卫生监管局 (ANVISA) 的网站,评估了菊科植物抗炎活性的技术趋势。和控制巴西的保健品和化妆品。该调查于 2008 年至 2018 年间在 Science Direct、Lilacs、PubMed 和 Web of Science(主要合集)以及 SciELO Citation Index 数据库中进行。专利调查是在德温特创新指数的基础上进行的,德温特创新指数是全球专利咨询的重要来源,涵盖了 20 年的注册专利。尽管在不同抗炎活性模型中对菊科物种进行了大量研究,但市场上关于这些物种的专利或产品用于此目的的记录很少。有些物种具有传统用途,甚至出现在巴西药典的植物疗法摘要中。该综述证实了菊科植物在开发抗炎药物方面的治疗潜力,并强调了发展能力和减少技术瓶颈以促进生物多样性产品研究和创新的必要性。其中涵盖了20年的注册专利。尽管在不同抗炎活性模型中对菊科物种进行了大量研究,但市场上关于这些物种的专利或产品用于此目的的记录很少。有些物种具有传统用途,甚至出现在巴西药典的植物疗法摘要中。该综述证实了菊科植物在开发抗炎药物方面的治疗潜力,并强调了发展能力和减少技术瓶颈以促进生物多样性产品研究和创新的必要性。其中涵盖了20年的注册专利。尽管在不同抗炎活性模型中对菊科物种进行了大量研究,但市场上关于这些物种的专利或产品用于此目的的记录很少。有些物种具有传统用途,甚至出现在巴西药典的植物疗法摘要中。该综述证实了菊科植物在开发抗炎药物方面的治疗潜力,并强调了发展能力和减少技术瓶颈以促进生物多样性产品研究和创新的必要性。为此目的,这些物种的专利或产品在市场上的记录很少。有些物种具有传统用途,甚至出现在巴西药典的植物疗法摘要中。该综述证实了菊科植物在开发抗炎药物方面的治疗潜力,并强调了发展能力和减少技术瓶颈以促进生物多样性产品研究和创新的必要性。为此目的,这些物种的专利或产品在市场上的记录很少。有些物种具有传统用途,甚至出现在巴西药典的植物疗法摘要中。该综述证实了菊科植物在开发抗炎药物方面的治疗潜力,并强调了发展能力和减少技术瓶颈以促进生物多样性产品研究和创新的必要性。
更新日期:2020-07-14
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