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Synthesis of Cyclopenta[b]indoles via a Formal [3+2] Cyclization of N‐Sulfonyl‐1,2,3‐triazoles and Indoles
Advanced Synthesis & Catalysis ( IF 5.4 ) Pub Date : 2020-07-14 , DOI: 10.1002/adsc.202000624
Shengguo Duan 1 , Wan Zhang 1 , Yuntong Hu 1 , Ze‐Feng Xu 1 , Chuan‐Ying Li 1
Affiliation  

Annulation of benzoxy‐tethered N‐sulfonyl‐1,2,3‐triazoles and indoles has been developed in this paper, providing an efficient and convenient access to valuable cyclopenta[b]indoles in moderate to good yields. α,β‐Unsaturated imine, which generated in situ from denitrogenation and 1,2‐OBz migration of triazole, provided three carbons for the formal [3+2] cyclization reaction for the first time.

中文翻译:

通过N-磺酰基-1,2,3-三唑和吲哚的形式[3 + 2]环化合成环戊[b]吲哚

本文开发了苯氧基束缚的N-磺酰基-1,2,3-三唑和吲哚的环化反应,可有效,方便地获得中度到良好收率的有价值的环戊[ b ]吲哚。由三唑的脱氮和1,2-OBz迁移原位产生的α,β-不饱和亚胺,首次为正式的[3 + 2]环化反应提供了三个碳。
更新日期:2020-09-05
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