Hypoxemia is a typical symptom of acute respiratory distress syndrome. To avoid pulmonary morbidity, low tidal volume ventilation is often applied. The ventilation strategy will certainly cause hypercapnia. This study aimed to explore whether hypercapnia would promote microglial pyroptosis via inhibiting mitophagy in adult rats with hypoxemia.

中文翻译：

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高碳酸血症通过抑制低氧成年大鼠的线粒体自噬促进小胶质细胞焦亡。

低氧血症是急性呼吸窘迫综合征的典型症状。为了避免肺部疾病，通常采用低潮气量通气。通气策略肯定会导致高碳酸血症。本研究旨在探讨高碳酸血症是否会通过抑制低氧血症成年大鼠的线粒体自噬促进小胶质细胞焦亡。