Black Phosphorus Nanosheets for Killing Bacteria through Nanoknife Effect,Particle & Particle Systems Characterization

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Black Phosphorus Nanosheets for Killing Bacteria through Nanoknife Effect
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-07-14 , DOI: 10.1002/ppsc.202000169
Tao Guo ₁ , Shihao Zhuang ₂ , Honglong Qiu ₃ , Yating Guo ₄ , Lili Wang ₅ , Guixiao Jin ₁ , Weiwen Lin ₅ , Guoming Huang ₃ , Huanghao Yang ₄

Affiliation

Black phosphorus (BP) has emerged as a rapidly rising star in the field of biomedical science. In this work, BP nanosheets (BPNSs) are synthesized and their potential as a nano‐antibacterial agent is investigated. The concentration and time‐dependent antibacterial activities are evaluated by cell viability assays together with scanning electron microscopy, confocal laser scanning microscope, and the measurement of efflux of RNA release assay. The experimental results show that BPNSs have a strong killing effect on both representatives of gram‐negative bacteria (Escherichia coli) and gram‐positive bacteria (Staphylococcus aureus), and exhibit concentration and time‐dependent antibacterial activity. The sharp edges of BPNSs in the interaction with bacteria can cause physical damage to the bacterial membrane and RNA leakage, resulting in bacterial death. The results demonstrate that the BPNSs show great promise as new nano‐antibacterial materials.

中文翻译：

黑色磷纳米片通过纳米刀效应杀死细菌

黑磷（BP）已成为生物医学领域迅速崛起的新星。在这项工作中，合成了BP纳米片（BPNSs），并研究了其作为纳米抗菌剂的潜力。通过细胞活力测定，扫描电子显微镜，共聚焦激光扫描显微镜以及RNA释放测定的流出物来评估浓度和时间依赖性抗菌活性。实验结果表明，BPNSs对革兰氏阴性菌（大肠杆菌）和革兰氏阳性菌（金黄色葡萄球菌）均具有强大的杀灭作用。），并表现出浓度和时间依赖性抗菌活性。BPNS与细菌相互作用的锋利边缘会导致细菌膜的物理损伤和RNA泄漏，从而导致细菌死亡。结果表明，BPNSs作为新型纳米抗菌材料具有广阔的前景。

更新日期：2020-07-14

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