Delineation of malformations of cortical development (MCD) is central in presurgical evaluation of drug‐resistant epilepsy. Delineation using magnetic resonance imaging (MRI) can be ambiguous, however, because the conventional T1‐ and T2‐weighted contrasts depend strongly on myelin for differentiation of cortical tissue and white matter. Variations in myelin content within both cortex and white matter may cause MCD findings on MRI to change size, become undetectable, or disagree with histopathology. The novel tensor‐valued diffusion MRI (dMRI) technique maps microscopic diffusion anisotropy, which is sensitive to axons rather than myelin. This work investigated whether tensor‐valued dMRI may improve differentiation of cortex and white matter in the delineation of MCD.

中文翻译：

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张量值扩散 MRI 在与癫痫相关的皮质发育畸形中区分皮质和白质

皮质发育畸形（MCD）的描述是耐药性癫痫的术前评估的核心。然而，使用磁共振成像 (MRI) 的描绘可能不明确，因为传统的 T1 和 T2 加权对比强烈依赖髓鞘来区分皮质组织和白质。皮质和白质内髓鞘含量的变化可能导致 MRI 上的 MCD 发现改变大小、变得无法检测或与组织病理学不一致。新的张量值扩散 MRI (dMRI) 技术绘制了微观扩散各向异性，它对轴突而不是髓鞘敏感。这项工作调查了张量值 dMRI 是否可以在 MCD 的描绘中改善皮层和白质的分化。