The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time.,BioEssays

当前位置： X-MOL 学术 › BioEssays › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

The HPA Axis under Stress and Aging: Individual Vulnerability is Associated with Behavioral Patterns and Exposure Time.
BioEssays ( IF 3.2 ) Pub Date : 2020-07-14 , DOI: 10.1002/bies.202000007
Nadezhda D Goncharova ₁

Affiliation

With aging, incidence of severe stress‐related diseases increases. However, mechanisms, underlying individual vulnerability to stress and age‐related diseases are not clear. The goal of this review is to analyze finding from the recent literature on age‐related characteristics of the hypothalamic‐pituitary‐adrenal (HPA) axis associated with stress reactivity in animals that show behavioral signs of anxiety and depression under mild stress, and in human patients with anxiety disorders and depression with emphasis on the impact of the circadian rhythm and the negative feedback mechanisms involved in the stress response. One can conclude that HPA axis reaction to psycho‐emotional stress, at least acute stress, increases in the aged individuals with anxiety and depression behavior. Elevated stress reactivity is associated with disruption of the circadian rhythm and the mineralocorticoid receptor‐mediated glucocorticoid negative feedback. The disordered function of the HPA axis in individuals with anxiety and depression behavior can contribute to aging‐related pathology.

中文翻译：

压力和衰老下的 HPA 轴：个人脆弱性与行为模式和暴露时间有关。

随着年龄的增长，严重的压力相关疾病的发病率增加。然而，个体对压力和年龄相关疾病的潜在脆弱性的机制尚不清楚。本综述的目的是分析最近文献中关于下丘脑-垂体-肾上腺 (HPA) 轴的年龄相关特征的发现，这些特征与在轻度压力下表现出焦虑和抑郁行为迹象的动物以及人类的应激反应相关。焦虑症和抑郁症患者，强调昼夜节律的影响和压力反应中涉及的负反馈机制。可以得出结论，在具有焦虑和抑郁行为的老年人中，HPA 轴对心理-情绪压力（至少是急性压力）的反应会增加。升高的应激反应与昼夜节律和盐皮质激素受体介导的糖皮质激素负反馈的破坏有关。具有焦虑和抑郁行为的个体的 HPA 轴功能紊乱可导致衰老相关病理。

更新日期：2020-08-26

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11