Microporous Biodegradable Films Promote Therapeutic Angiogenesis.,Advanced Healthcare Materials

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Microporous Biodegradable Films Promote Therapeutic Angiogenesis.
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2020-07-14 , DOI: 10.1002/adhm.202000806
Eseelle K Hendow ₁ , Mehran Moazen ₂ , Francesco Iacoviello ₃ , Laurent Bozec ₄ , Caroline Pellet-Many ₅ , Richard M Day ₁

Affiliation

Peripheral arterial disease and critical limb ischemia are common symptoms of cardiovascular disease. Vascular surgery is used to create a bypass around occluded blood vessels to improve blood flow to ischemic muscle, thus avoiding the need for amputation. Attempts to vascularize tissues by therapeutic angiogenesis using delivery of exogenous angiogenic agents are underwhelming. A material‐based approach that provides an endogenous stimulus capable of promoting angiogenesis and increased tissue perfusion would provide a paradigm shift in treatment options available. It is reported here that microporous biodegradable films produced using thermally induced phase separation provide a localized biophysical stimulus of proangiogenic genes in vivo that is associated with increased blood vessel density and restoration of blood flow to ischemic tissue. These findings show, for the first time, that acellular, nonfunctionalized biodegradable biomaterials can provide an innovative, material‐based approach for therapeutic angiogenesis to enhance tissue reperfusion in vivo.

中文翻译：

微孔可生物降解薄膜促进治疗性血管生成。

外周动脉疾病和严重肢体缺血是心血管疾病的常见症状。血管手术用于在闭塞血管周围建立旁路，以改善缺血肌肉的血流，从而避免截肢的需要。使用外源性血管生成剂的递送来通过治疗性血管生成来使组织血管化的尝试并不令人印象深刻。基于材料的方法提供能够促进血管生成和增加组织灌注的内源性刺激，这将为可用的治疗方案提供范式转变。据报道，使用热诱导相分离生产的微孔可生物降解薄膜提供了体内促血管生成基因的局部生物物理刺激，这与血管密度的增加和缺血组织血流的恢复有关。这些发现首次表明，无细胞、非功能化的可生物降解生物材料可以为治疗性血管生成提供一种创新的、基于材料的方法，以增强体内组织再灌注。

更新日期：2020-09-10

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