Abstract Gastrointestinal tract cancers are among the most common malignancies that still lack reliable and highly specific biomarkers. Differential scanning calorimetry has been widely explored in the last decade for the detection of disease- and stage-specific changes in temperature-induced conformational transitions in blood plasma proteins. The goal of the present study was to explore the potential of calorimetry to follow colorectal cancer tumor development in rats treated with 1,2-dimethylhydrazine. The plasma calorimetric features are related to the sex, age and occurrence of proliferative lesions and tumor formations in the intestinal tract of treated animals. The process of tumor induction led to both stabilization of the plasma proteome and decreased similarity between the plasma calorimetric curves of healthy and diseased rats; therefore, these parameters might be regarded as indicators of malignant transformation of intestinal cells and progression of tumor formation.

中文翻译：

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在实验性大鼠模型中跟踪结直肠癌发展的量热法

摘要胃肠道癌症是最常见的恶性肿瘤之一，仍然缺乏可靠和高度特异性的生物标志物。差示扫描量热法在过去十年中被广泛探索，用于检测温度诱导的血浆蛋白构象转变的疾病和阶段特异性变化。本研究的目的是探索量热法在用 1,2-二甲基肼治疗的大鼠中跟踪结直肠癌肿瘤发展的潜力。血浆量热特征与性别、年龄以及治疗动物肠道中增殖性病变和肿瘤形成的发生率有关。肿瘤诱导过程导致血浆蛋白质组的稳定和健康和患病大鼠血浆量热曲线之间的相似性降低；